alh-7 Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: alh-7
Official Full Name: Aldehyde dehydrogenase domain-containing protein
Primary source: WormBase:WBGene00000113
Locus tag: CELE_F45H10.1
See related: AllianceGenome:WB:WBGene00000113
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable succinate-semialdehyde dehydrogenase (NAD+) activity. Predicted to be involved in gamma-aminobutyric acid catabolic process. Predicted to be active in mitochondrion. Is expressed in hypodermis; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See alh-7 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (13487243..13491786, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F45H10.2 (e-PCR)
- UniSTS:315795

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aldehyde dehydrogenase domain-containing protein

NP_001254393.1

Confirmed by transcript evidence

NP_001367295.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13487243..13491786 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001267464.3 → NP_001254393.1 Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254393.1

Status: REVIEWED

UniProtKB/TrEMBL

O02266

Conserved Domains (1) summary

cd07103
Location:37 → 490

ALDH_F5_SSADH_GabD; Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like
NM_001381642.1 → NP_001367295.1 Aldehyde dehydrogenase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G3MU66

Conserved Domains (1) summary

cl11961
Location:1 → 202

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily