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    rfe UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase [ Mycobacterium canettii CIPT 140010059 ]

    Gene ID: 45425276, updated on 11-Dec-2024

    Summary

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    Gene symbol
    rfe
    Gene description
    UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase
    Locus tag
    MCAN_RS06935
    Gene type
    protein coding
    Organism
    Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
    Lineage
    Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Old locus tag
    MCAN_13191
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    Genomic context

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    Sequence:
    NC_015848.1 (1482762..1483976)

    NC_015848.1Genomic Context describing neighboring genes Neighboring gene peptide chain release factor N(5)-glutamine methyltransferase Neighboring gene L-threonylcarbamoyladenylate synthase Neighboring gene ATP synthase subunit I Neighboring gene F0F1 ATP synthase subunit A Neighboring gene F0F1 ATP synthase subunit C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015848.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mycobacterial lipid II is composed of a complex mixture of modified muramyl and peptide moieties linked to decaprenyl phosphate. Mahapatra S, et al. J Bacteriol, 2005 Apr. PMID 15805521, Free PMC Article
    2. N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis. Huszár S, et al. Antimicrob Agents Chemother, 2017 Nov. PMID 28874370, Free PMC Article
    3. Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors. Mitachi K, et al. Anal Biochem, 2016 Nov 1. PMID 27530653, Free PMC Article
    4. Inhibition of the first step in synthesis of the mycobacterial cell wall core, catalyzed by the GlcNAc-1-phosphate transferase WecA, by the novel caprazamycin derivative CPZEN-45. Ishizaki Y, et al. J Biol Chem, 2013 Oct 18. PMID 23986448, Free PMC Article
    5. Mycobacterium tuberculosis Rv1302 and Mycobacterium smegmatis MSMEG_4947 have WecA function and MSMEG_4947 is required for the growth of M. smegmatis. Jin Y, et al. FEMS Microbiol Lett, 2010 Sep 1. PMID 20637039

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase
    WP_003898816.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015848.1 Reference assembly

      Range
      1482762..1483976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_003898816.1 MULTISPECIES: UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase [Mycobacterium]

      See identical proteins and their annotated locations for WP_003898816.1

      UniProtKB/Swiss-Prot
      L0T8Z6, P9WMW4, P9WMW5, Q10606
      UniProtKB/TrEMBL
      A0A045JVD7, A0A0H3L942, A0A8I0ENF4, A0AAW8I0P2, A5U201, R4M7I4
      Conserved Domains (1) summary
      cd06853
      Location:67 → 341
      GT_WecA_like; This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond ...
    Nucleotide Protein
    Heading Accession and Version

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