Cntnap4 contactin associated protein-like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cntnap4provided by MGI
Official Full Name: contactin associated protein-like 4provided by MGI
Primary source: MGI:MGI:2183572
See related: Ensembl:ENSMUSG00000031772 AllianceGenome:MGI:2183572
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Caspr4; E130114F09Rik
Summary: Enables PDZ domain binding activity. Involved in modulation of chemical synaptic transmission; regulation of grooming behavior; and regulation of synapse organization. Acts upstream of or within neural precursor cell proliferation and neuron differentiation. Located in dendrite and plasma membrane. Is active in GABA-ergic synapse and presynaptic membrane. Is expressed in brain; dentate gyrus subgranular zone; and thalamus. Orthologous to human CNTNAP4 (contactin associated protein family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 7.4), CNS E18 (RPKM 5.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 58.7 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (113296523..113609339)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (112569798..112882707)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
Title: Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
Cntnap4 partial deficiency exacerbates alpha-synuclein pathology through astrocyte-microglia C3-C3aR pathway.
Title: Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway.
Lactobacillus reuteri normalizes altered fear memory in male Cntnap4 knockout mice.
Title: Lactobacillus reuteri normalizes altered fear memory in male Cntnap4 knockout mice.
CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.
Title: CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.
Down-regulation or overexpression of CNTNAP4 in the hippocampus influenced the expression of gamma-aminobutyric acid A receptor beta2/3 membrane protein, without affecting total GABAARbeta2/3 protein concentration in epileptic mice
Title: CNTNAP4 Impacts Epilepsy Through GABAA Receptors Regulation: Evidence From Temporal Lobe Epilepsy Patients and Mouse Models.
a novel biological functional axis for Nell-1 and Cntnap4 in osteogenesis and, potentially, in neural development and function, is reported.
Title: Neurexin Superfamily Cell Membrane Receptor Contactin-Associated Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1 (Nell-1)-Responsive Osteogenesis.
Caspr4 inhibits neuronal differentiation in a LNX-dependent manner.
Title: Caspr4 interaction with LNX2 modulates the proliferation and neuronal differentiation of mouse neural progenitor cells.
Cntnap4 is localized presynaptically and its loss leads to a reduction in the output of cortical parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acid producing) basket cells.
Title: Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

D8Mit152 (e-PCR), detects polymorphism
- UniSTS:131357

D8Mit199 (e-PCR), detects polymorphism
- UniSTS:131406

D19Got36 (e-PCR)
- UniSTS:114301

D8Mit270 (e-PCR), detects polymorphism
- UniSTS:131481

RH118318 (e-PCR)
- UniSTS:160959

NoName (e-PCR)
- UniSTS:236009

D8Mit353 (e-PCR), detects polymorphism
- UniSTS:131568

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in presynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: contactin-associated protein-like 4

Names: cell recognition molecule Caspr4; cell recognition protein CASPR4; contactin associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130457.2 → NP_569724.2 contactin-associated protein-like 4 precursor

See identical proteins and their annotated locations for NP_569724.2

Status: PROVISIONAL

Source sequence(s)

BC034628

Consensus CDS

CCDS40482.1

UniProtKB/Swiss-Prot

Q8K002, Q99P47

UniProtKB/TrEMBL

D3YWB9

Related

ENSMUSP00000034225.7, ENSMUST00000034225.7

Conserved Domains (6) summary

smart00231
Location:57 → 179

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:56 → 178

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:796 → 940

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:555 → 586

EGF; EGF-like domain

pfam02210
Location:214 → 343

Laminin_G_2; Laminin G domain

cl00085
Location:597 → 645

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

113296523..113609339

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530730.3 → XP_006530793.1 contactin-associated protein-like 4 isoform X2

Conserved Domains (2) summary

cd00110
Location:161 → 305

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:413 → 540

Laminin_G_2; Laminin G domain
XM_030243313.2 → XP_030099173.1 contactin-associated protein-like 4 isoform X2

Conserved Domains (2) summary

cd00110
Location:161 → 305

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:413 → 540

Laminin_G_2; Laminin G domain
XM_006530729.5 → XP_006530792.1 contactin-associated protein-like 4 isoform X1

Conserved Domains (4) summary

cd00110
Location:525 → 669

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl00085
Location:326 → 374

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam00008
Location:284 → 315

EGF; EGF-like domain

pfam02210
Location:777 → 904

Laminin_G_2; Laminin G domain