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    Ddx19a DEAD box helicase 19a [ Mus musculus (house mouse) ]

    Gene ID: 13680, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ddx19aprovided by MGI
    Official Full Name
    DEAD box helicase 19aprovided by MGI
    Primary source
    MGI:MGI:99526
    See related
    Ensembl:ENSMUSG00000015023 AllianceGenome:MGI:99526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DBP5; Ddx19; Eif4a-rs1
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in cytoplasmic stress granule and nucleus. Is expressed in several structures, including central nervous system and sensory organ. Orthologous to human DDX19A (DEAD-box helicase 19A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 23.6), liver E14 (RPKM 17.2) and 28 other tissues See more
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    Genomic context

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    See Ddx19a in Genome Data Viewer
    Location:
    8 E1; 8 57.86 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111701623..111724456, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110974991..110997823, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 46052 Neighboring gene predicted gene, 39251 Neighboring gene STARR-positive B cell enhancer ABC_E1770 Neighboring gene STARR-seq mESC enhancer starr_22687 Neighboring gene predicted gene, 51551 Neighboring gene DEAD box helicase 19b Neighboring gene microRNA 3473d Neighboring gene STARR-positive B cell enhancer ABC_E566 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene exosome component 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation. Pinter S, et al. Nucleic Acids Res, 2021 May 7. PMID 33823549, Free PMC Article
    2. DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation. Zhang K, et al. Cell Rep, 2019 Jan 29. PMID 30699353
    3. RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1. Rajakylä EK, et al. Nat Commun, 2015 Jan 14. PMID 25585691, Free PMC Article
    4. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Yang HS, et al. Mol Cell Biol, 2003 Jan. PMID 12482958, Free PMC Article
    5. Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals. Gee SL, et al. Gene, 1994 Mar 25. PMID 8144024

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
      Title: A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation.
    2. Ddx19 is an RNA export factor required for nuclear import of the SRF coactivator MKL1
      Title: RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX19A
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a
    DEAD box RNA helicase DEAD5
    DEAD box protein 19A
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19
    Ddx19-like protein
    eukaryotic translation initiation factor 4A-related sequence 1
    mDEAD5
    NP_001404111.1
    NP_031942.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417182.1 → NP_001404111.1  ATP-dependent RNA helicase DDX19A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093451, AC132945

    2. NM_007916.2 → NP_031942.2  ATP-dependent RNA helicase DDX19A isoform 1

      See identical proteins and their annotated locations for NP_031942.2

      Status: VALIDATED

      Source sequence(s)
      AK146548, BG094410, BY302446
      Consensus CDS
      CCDS22668.1
      UniProtKB/Swiss-Prot
      Q543M2, Q61655, Q921R0
      Related
      ENSMUSP00000047898.8, ENSMUST00000040416.8
      Conserved Domains (3) summary
      PTZ00424
      Location:90 → 468
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:306 → 441
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:93 → 295
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111701623..111724456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61655.2 GenPept UniProtKB/Swiss-Prot:Q61655

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