Foxo6 forkhead box O6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxo6provided by MGI
Official Full Name: forkhead box O6provided by MGI
Primary source: MGI:MGI:2676586
See related: Ensembl:ENSMUSG00000052135 AllianceGenome:MGI:2676586
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in memory; positive regulation of dendritic spine development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including nervous system; olfactory epithelium; renal cortex; stomach; and thymus. Orthologous to human FOXO6 (forkhead box O6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in small intestine adult (RPKM 9.5), whole brain E14.5 (RPKM 8.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4 56.1 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (120124275..120144458, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (120267078..120287261, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation.
Title: FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation.
Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo.
Title: Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo.
Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation.
Title: Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation.
FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity.
Title: FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity.
we assume that FoxO6-mediated IL-1beta is involved in hepatic inflammation and insulin resistance via TF/PAR2 pathway in the liver.
Title: FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice.
data indicate that FoxO6 depletion protected against diet-induced glucose intolerance and insulin resistance by attenuating hepatic gluconeogenesis and curbing macrophage infiltration in liver and adipose tissues in mice.
Title: Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice.
FoxO6 is an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production
Title: FoxO6 integrates insulin signaling with MTP for regulating VLDL production in the liver.
Studies indicate that FoxO6 is produced in the liver of both rodents and humans.
Title: FoxO6 in glucose metabolism (FoxO6).
FoxO6 represses the expression of PGC-1alpha via direct binding to an upstream A/T-rich element (AAGATATCAAAACA,-2228-2215) in the PGC-1alpha promoter.
Title: FoxO6 and PGC-1α form a regulatory loop in myogenic cells.
FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus
Title: FoxO6 regulates memory consolidation and synaptic function.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: forkhead box protein O6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194060.1 → NP_918949.1 forkhead box protein O6

See identical proteins and their annotated locations for NP_918949.1

Status: PROVISIONAL

Source sequence(s)

AJ571690

Consensus CDS

CCDS18588.1

UniProtKB/Swiss-Prot

Q70KY4

UniProtKB/TrEMBL

Q5RJI9

Related

ENSMUSP00000099716.4, ENSMUST00000102656.4

Conserved Domains (3) summary

cd00059
Location:88 → 168

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16675
Location:358 → 380

FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2

pfam16676
Location:499 → 537

FOXO-TAD; Transactivation domain of FOXO protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

120124275..120144458 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240558.4 → XP_011238860.1 forkhead box protein O6 isoform X1

Conserved Domains (4) summary

PRK12323
Location:93 → 272

PRK12323; DNA polymerase III subunit gamma/tau

pfam16675
Location:244 → 266

FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2

pfam16676
Location:385 → 423

FOXO-TAD; Transactivation domain of FOXO protein family

cl00061
Location:25 → 56

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...