ddl-1 WASH complex subunit homolog 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ddl-1
Official Full Name: WASH complex subunit homolog 3
Primary source: WormBase:WBGene00019125
Locus tag: CELE_F59E12.10
See related: AllianceGenome:WB:WBGene00019125
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in cytoplasmic sequestering of protein and determination of adult lifespan. Located in cytoplasm. Is expressed in several structures, including intestine; neurons; pharynx; spermatheca; and vulval muscle. Orthologous to human WASHC3 (WASH complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ddl-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (5647159..5647884, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that the proteins DDL-1 and DDL-2, previously implicated in life span extension, modulate HSF-1 activity by forming an inhibitory heterocomplex with HSF-1 and that formation of this complex is regulated by Insulin/IGF-1-like signaling.
Title: HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F59E12.11 (e-PCR)
- UniSTS:311305

F59E12.10 (e-PCR)
- UniSTS:320736

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic sequestering of protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of WASH complex	IBA Inferred from Biological aspect of Ancestor more info
part_of WASH complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WASH complex subunit homolog 3

NP_001370457.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5647159..5647884 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383847.2 → NP_001370457.1 WASH complex subunit homolog 3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O01901

Conserved Domains (1) summary

pfam10152
Location:28 → 158

CCDC53; Subunit CCDC53 of WASH complex