mek-5 mitogen-activated protein kinase kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mek-5
Official Full Name: mitogen-activated protein kinase kinase
Primary source: WormBase:WBGene00304811
Locus tag: CELE_E02D9.3
See related: AllianceGenome:WB:WBGene00304811
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mek-5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (6802200..6804860)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C37A2.1 (e-PCR)
- UniSTS:309272

E02D9.1 (e-PCR)
- UniSTS:313984

C37A2.8 (e-PCR)
- UniSTS:308735

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitogen-activated protein kinase kinase

NP_740881.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6802200..6804860

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170892.4 → NP_740881.1 mitogen-activated protein kinase kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740881.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9TYV7

Conserved Domains (1) summary

smart00220
Location:163 → 406

S_TKc; Serine/Threonine protein kinases, catalytic domain