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    cyp-31A3 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 189467, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp-31A3
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00021200
    Locus tag
    CELE_Y17G9B.3
    See related
    AllianceGenome:WB:WBGene00021200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in several processes, including asymmetric cell division; eggshell formation; and polar body extrusion after meiotic divisions. Predicted to be located in membrane. Is expressed in gonad and oocyte. Used to study Bietti crystalline corneoretinal dystrophy. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-31A3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (4761049..4762885)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SGF29 C-terminal domain-containing protein Neighboring gene MEiosis-to-MItosis transition associated Neighboring gene Uncharacterized protein Neighboring gene Nucleoporin GLE1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo. Benenati G, et al. Mech Dev, 2009 May-Jun. PMID 19368796
    2. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of both cyp-31A2 and cyp-31A3 either by RNAi or using a double deletion mutant, led to the failure of establishing the correct polarity of the embryo and to complete the extrusion of the polar bodies during meiosis.
      Title: Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eggshell formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polar body extrusion after meiotic divisions IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CYtochrome P450 family
    NP_500637.2
    • Product from WormBase gene class cyp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4761049..4762885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068236.4 → NP_500637.2  CYtochrome P450 family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500637.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N574
      Conserved Domains (1) summary
      pfam00067
      Location:36 → 472
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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