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    mff-2 Mitochondrial fission factor [ Caenorhabditis elegans ]

    Gene ID: 3565409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mff-2
    Official Full Name
    Mitochondrial fission factor
    Primary source
    WormBase:WBGene00018894
    Locus tag
    CELE_F55F8.6
    See related
    AllianceGenome:WB:WBGene00018894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial fission; positive regulation of mitochondrial fission; and positive regulation of protein targeting to membrane. Predicted to be located in mitochondrial outer membrane and peroxisome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mff-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (5657917..5658712, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CBF1-interacting co-repressor CIR N-terminal domain-containing protein Neighboring gene Ribosome biogenesis protein WDR12 homolog Neighboring gene Protein-tyrosine-phosphatase Neighboring gene SSD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Shen Q, et al. Mol Biol Cell, 2014 Jan. PMID 24196833, Free PMC Article
    2. Alcohol induces mitochondrial fragmentation and stress responses to maintain normal muscle function in Caenorhabditis elegans. Oh KH, et al. FASEB J, 2020 Jun. PMID 32294300, Free PMC Article
    3. Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways. Machiela E, et al. FASEB J, 2020 Jun. PMID 32385951, Free PMC Article
    4. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans. Emerson FJ, et al. Nat Commun, 2024 Mar 14. PMID 38485937, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial fission factor
    NP_001370753.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5657917..5658712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383128.2 → NP_001370753.1  Mitochondrial fission factor [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91344
      Conserved Domains (1) summary
      pfam05644
      Location:105 → 160
      Miff; Mitochondrial and peroxisomal fission factor Mff
    Nucleotide Protein
    Heading Accession and Version

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