Stk36 serine/threonine kinase 36 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk36provided by MGI
Official Full Name: serine/threonine kinase 36provided by MGI
Primary source: MGI:MGI:1920831
See related: Ensembl:ENSMUSG00000033276 AllianceGenome:MGI:1920831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FU; Fused; mKIAA1278; B930045J24; 1700112N14Rik
Summary: Predicted to enable protein serine/threonine kinase activity and transcription corepressor binding activity. Involved in several processes, including cilium assembly; positive regulation of smoothened signaling pathway; and smoothened signaling pathway. Acts upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Located in cytoplasm. Is expressed in several structures, including central nervous system; sensory organ; skeleton; tail somite; and testis. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 49.4), whole brain E14.5 (RPKM 6.3) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 38.54 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74640583..74676053)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74601391..74636894)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
Title: ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
Title: Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
Hydrocephalus and suppurative otitis media indicate dysfunction of motile cilia in Stk36 null mice
Title: Congenital hydrocephalus in genetically engineered mice.
mouse Fu is essential for construction of the central pair apparatus of motile, 9+2 cilia
Title: Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.
This growth inhibition is partially rescued by expression of ectopic Gli1, suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.
Title: Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_21861-21862:1027094738:1 (e-PCR)
- UniSTS:268654

NoName (e-PCR)
- UniSTS:548508

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in axoneme assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase 36

Names: fused homolog; serine/threonine kinase 36 (fused homolog, Drosophila)

NP_001391006.1

EC 2.7.11.1

NP_001391007.1

EC 2.7.11.1

NP_778196.2

EC 2.7.11.1

XP_036021382.1

EC 2.7.11.1

XP_036021383.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001404077.1 → NP_001391006.1 serine/threonine-protein kinase 36 isoform 2

Status: VALIDATED

Source sequence(s)

AC117610
NM_001404078.1 → NP_001391007.1 serine/threonine-protein kinase 36 isoform 3

Status: VALIDATED

Source sequence(s)

AC117610

Related

ENSMUSP00000084433.5, ENSMUST00000087186.11
NM_175031.4 → NP_778196.2 serine/threonine-protein kinase 36 isoform 1

See identical proteins and their annotated locations for NP_778196.2

Status: VALIDATED

Source sequence(s)

AC117610

Consensus CDS

CCDS35619.1

UniProtKB/Swiss-Prot

Q69ZM6, Q6PDI0, Q80XQ6

Related

ENSMUSP00000084430.5, ENSMUST00000087183.11

Conserved Domains (2) summary

smart00220
Location:4 → 254

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

RNA

NR_175802.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117610
NR_175803.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117610

Related

ENSMUST00000145673.8
NR_175804.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117610
NR_175805.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117610

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

74640583..74676053

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165489.1 → XP_036021382.1 serine/threonine-protein kinase 36 isoform X2

Conserved Domains (1) summary

cd14002
Location:2 → 254

STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
XM_036165490.1 → XP_036021383.1 serine/threonine-protein kinase 36 isoform X3

Conserved Domains (4) summary

COG1413
Location:907 → 1152

HEAT; HEAT repeat [General function prediction only]

sd00044
Location:962 → 989

HEAT; HEAT repeat [structural motif]

pfam13646
Location:1028 → 1123

HEAT_2; HEAT repeats

cl21453
Location:10 → 118

PKc_like; Protein Kinases, catalytic domain