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    Ggnbp1 gametogenetin binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 70772, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ggnbp1provided by MGI
    Official Full Name
    gametogenetin binding protein 1provided by MGI
    Primary source
    MGI:MGI:3055306
    See related
    Ensembl:ENSMUSG00000048731 AllianceGenome:MGI:3055306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mdf; 0610031G08Rik
    Summary
    Involved in mitochondrial fission. Located in Golgi apparatus; mitochondrial intermembrane space; and plasma membrane. Is expressed in ductus deferens; epididymis; jejunum; and testis. Orthologous to human GGNBP1 (gametogenetin binding protein 1 (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 178.0) and kidney adult (RPKM 10.5) See more
    Orthologs
    human all
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    Genomic context

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    See Ggnbp1 in Genome Data Viewer
    Location:
    17 A3.3; 17 13.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27237009..27255352)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27018035..27036378)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene synaptic Ras GTPase activating protein 1 homolog (rat) Neighboring gene microRNA 3083b Neighboring gene microRNA 3083 Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27137073-27137182 Neighboring gene STARR-positive B cell enhancer ABC_E11633 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27164461-27164644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27165231-27165340 Neighboring gene STARR-seq mESC enhancer starr_42142 Neighboring gene BCL2-antagonist/killer 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27193173-27193441 Neighboring gene inositol 1,4,5-triphosphate receptor 3 Neighboring gene microRNA 7677 Neighboring gene inositol 1,4,5-triphosphate receptor 3, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GGNBP1 ensures proper spermiogenesis in response to stress in mice. Han T, et al. Biochem Biophys Res Commun, 2020 May 7. PMID 32139124
    2. A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in mitochondrial morphogenesis during spermatogenesis in mice. Aihara T, et al. Biol Reprod, 2009 Apr. PMID 19208545
    3. Identification and characterization of a novel testicular germ cell-specific gene Ggnbp1. Zhou Y, et al. Mol Reprod Dev, 2005 Mar. PMID 15625700
    4. Germ-cell specific protein gametogenetin protein 2 (GGN2), expression in the testis, and association with intracellular membrane. Zhao Q, et al. Mol Reprod Dev, 2005 Sep. PMID 15892049
    5. Mouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcription. Brower CS, et al. J Biol Chem, 2010 May 28. PMID 20356838, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GGNBP1 ensures proper spermiogenesis in response to stress in mice.
      Title: GGNBP1 ensures proper spermiogenesis in response to stress in mice.
    2. GGNBP1 is involved in spermatogenesis by modifying mitochondrial dynamics and morphology.
      Title: A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in mitochondrial morphogenesis during spermatogenesis in mice.
    3. A testicular germ cell-specific protein interacting with GGN1. The protein seems to associate with the membrane system in the germ cell.
      Title: Identification and characterization of a novel testicular germ cell-specific gene Ggnbp1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Zbtb9

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gametogenetin-binding protein 1
    Names
    deubiquitinating enzyme Usp15
    gametogenin binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001251881.1 → NP_001238810.1  gametogenetin-binding protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and includes two alternate exons in the 5' UTR and CDS, compared to variant 1. It encodes isoform b, which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AA388242, CF585840, CO041745
      Consensus CDS
      CCDS57061.1
      UniProtKB/TrEMBL
      D3Z3W4
      Related
      ENSMUSP00000113880.2, ENSMUST00000122106.9
      Conserved Domains (1) summary
      pfam14836
      Location:173 → 260
      Ubiquitin_3; Ubiquitin-like domain

    2. NM_027544.2 → NP_081820.2  gametogenetin-binding protein 1 isoform a

      See identical proteins and their annotated locations for NP_081820.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK077129, AY141192, BB018101
      Consensus CDS
      CCDS28559.1
      UniProtKB/Swiss-Prot
      B9WZ58, Q6K1E7, Q8C5T9
      Related
      ENSMUSP00000051800.7, ENSMUST00000053683.7
      Conserved Domains (1) summary
      pfam14836
      Location:281 → 368
      Ubiquitin_3; Ubiquitin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      27237009..27255352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6K1E7.2 GenPept UniProtKB/Swiss-Prot:Q6K1E7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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