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    RXT2 Rxt2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RXT2
    Official Full Name
    Rxt2p
    Primary source
    SGD:S000000299
    Locus tag
    YBR095C
    See related
    AllianceGenome:SGD:S000000299; FungiDB:YBR095C; VEuPathDB:YBR095C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RAF60
    Summary
    Contributes to histone deacetylase activity. Involved in several processes, including invasive growth in response to glucose limitation; negative regulation of heterochromatin formation; and positive regulation of invasive growth in response to glucose limitation. Located in cytosol and nucleus. Part of Rpd3L complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RXT2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (434406..435698, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene acid phosphatase PHO5 Neighboring gene putative tubulin tyrosine ligase Neighboring gene uncharacterized protein Neighboring gene ubiquitin-binding serine/threonine protein kinase VPS15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum. Mogg C, et al. mBio, 2019 Jun 11. PMID 31186319, Free PMC Article
    2. Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae. Colina AR, et al. J Biol Chem, 2005 Dec 30. PMID 16275642
    3. Identification of novel genes involved in neutral lipid storage by quantitative trait loci analysis of Saccharomyces cerevisiae. Pačnik K, et al. BMC Genomics, 2021 Feb 9. PMID 33563210, Free PMC Article
    4. Toggle involving cis-interfering noncoding RNAs controls variegated gene expression in yeast. Bumgarner SL, et al. Proc Natl Acad Sci U S A, 2009 Oct 27. PMID 19805129, Free PMC Article
    5. Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics. Sardiu ME, et al. PLoS One, 2009 Oct 6. PMID 19806189, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L complex HDA PubMed 
    part_of Rpd3L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L-Expanded complex HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rxt2p
    NP_009653.2
    • Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      434406..435698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178443.1 → NP_009653.2  TPA: Rxt2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009653.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ96, P38255
      UniProtKB/TrEMBL
      D3UEJ0, G2W9A2, N1P848
      Conserved Domains (1) summary
      pfam08595
      Location:62 → 221
      RXT2_N; RXT2-like, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38255.2

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