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    TREML4 triggering receptor expressed on myeloid cells like 4 [ Homo sapiens (human) ]

    Gene ID: 285852, updated on 10-Dec-2024

    Summary

    Official Symbol
    TREML4provided by HGNC
    Official Full Name
    triggering receptor expressed on myeloid cells like 4provided by HGNC
    Primary source
    HGNC:HGNC:30807
    See related
    Ensembl:ENSG00000188056 MIM:614664; AllianceGenome:HGNC:30807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TLT4; TLT-4
    Summary
    Predicted to enable signaling receptor activity. Involved in positive regulation of toll-like receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum; endosome membrane; and lysosomal membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TREML4 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41228349..41238882)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41057643..41068182)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41196087..41206620)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24504 Neighboring gene triggering receptor expressed on myeloid cells like 3, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:41182302-41183501 Neighboring gene uncharacterized LOC105375055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41190561-41191060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41206864-41207400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41207401-41207935 Neighboring gene RNA, 5S ribosomal pseudogene 207 Neighboring gene triggering receptor expressed on myeloid cells like 5, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC126829

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of toll-like receptor 7 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of toll-like receptor 7 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    trem-like transcript 4 protein
    Names
    TREM like transcript 4
    triggering receptor expressed on myeloid cells-like protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198153.3NP_937796.1  trem-like transcript 4 protein precursor

      See identical proteins and their annotated locations for NP_937796.1

      Status: VALIDATED

      Source sequence(s)
      AL391903, AY358271
      Consensus CDS
      CCDS34446.1
      UniProtKB/Swiss-Prot
      B7ZL92, Q6UXN2
      Related
      ENSP00000342570.2, ENST00000341495.7
      Conserved Domains (2) summary
      cd05716
      Location:27121
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:25129
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      41228349..41238882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      41057643..41068182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)