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    GlcAT-P Glucuronyltransferase P [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39262, updated on 14-Nov-2024

    Summary

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    Official Symbol
    GlcAT-Pprovided by FlyBase
    Official Full Name
    Glucuronyltransferase Pprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036144
    Locus tag
    Dmel_CG6207
    See related
    AllianceGenome:FB:FBgn0036144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6207; dGlcAT-BSII; dGlcAT-P; DGlcAT-P; Dmel\CG6207; DmGlcAT-BSII
    Summary
    Enables glucuronosyltransferase activity. Involved in cellular glucuronidation and peripheral nervous system development. Located in Golgi apparatus. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; gland; larval glial cell; and mesoderm. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See GlcAT-P in Genome Data Viewer
    Location:
    68B1-68B1; 3-35 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11176954..11197536, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11170054..11190636, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene aarF domain containing kinase 5 Neighboring gene uncharacterized protein Neighboring gene procollagen lysyl hydroxylase Neighboring gene uncharacterized protein Neighboring gene noktochor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids. Kim BT, et al. J Biol Chem, 2003 Mar 14. PMID 12511570
    2. Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles. Itoh K, et al. Dev Biol, 2018 Apr 15. PMID 29499182, Free PMC Article
    3. Mucin-Type O-Glycosylation in the Drosophila Nervous System. Itoh K, et al. Front Neuroanat, 2021. PMID 34733141, Free PMC Article
    4. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. Valoskova K, et al. Elife, 2019 Mar 26. PMID 30910009, Free PMC Article
    5. Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Goodman RM, et al. Development, 2006 Dec. PMID 17108000

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study confirms results showing that GlcAT-S and GlcAT-P can transfer GlcA to the O-linked T-antigen as well as to N-linked LacNAc-chains in vitro.
      Title: Functional Analysis of the Glucuronyltransferases GlcAT-P and GlcAT-S of Drosophila melanogaster: Distinct Activities towards the O-linked T-antigen.
    2. novel glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans
      Title: Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetyllactosamine beta-1,3-glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables asioloorosomucoid beta-1,3-glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycoprotein biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteoglycan biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucuronyltransferase P
    Names
    CG6207-PA
    CG6207-PB
    CG6207-PC
    CG6207-PD
    CG6207-PE
    GlcAT-P-PA
    GlcAT-P-PB
    GlcAT-P-PC
    GlcAT-P-PD
    GlcAT-P-PE
    beta1,3-glucuronyltransferase-P
    NP_001014581.1
    NP_001246713.1
    NP_001246714.1
    NP_648448.1
    NP_729685.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11176954..11197536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259785.2 → NP_001246714.1  glucuronyltransferase P, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1U5
      Conserved Domains (1) summary
      cd00218
      Location:68 → 289
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

    2. NM_001259784.2 → NP_001246713.1  glucuronyltransferase P, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BI43, Q8MSC2, Q95RU4, Q9VTG7
      UniProtKB/TrEMBL
      A2RVE7, M9NE76
      Conserved Domains (1) summary
      cd00218
      Location:231 → 452
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

    3. NM_001014581.3 → NP_001014581.1  glucuronyltransferase P, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1U5
      Conserved Domains (1) summary
      cd00218
      Location:68 → 289
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

    4. NM_140191.3 → NP_648448.1  glucuronyltransferase P, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BI43, Q8MSC2, Q95RU4, Q9VTG7
      UniProtKB/TrEMBL
      A2RVE7, M9NE76
      Related
      FBpp0075919
      Conserved Domains (1) summary
      cd00218
      Location:231 → 452
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis

    5. NM_168451.4 → NP_729685.2  glucuronyltransferase P, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729685.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1U5
      Conserved Domains (1) summary
      cd00218
      Location:68 → 289
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V1U5 A4V1U5
    M9NE76 M9NE76
    Q9VTG7.1 Q9VTG7

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