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    CG8243 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35890, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8243provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033349
    Locus tag
    Dmel_CG8243
    See related
    AllianceGenome:FB:FBgn0033349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8243; gap40; SMAP
    Summary
    Predicted to enable GTPase activator activity. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Used to study candidiasis. Orthologous to several human genes including SMAP2 (small ArfGAP2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8243 in Genome Data Viewer
    Location:
    44F7-44F8; 2-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8922785..8925346)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4810290..4812851)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lines Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spitting Image Neighboring gene uncharacterized protein Neighboring gene aaRS-interacting multifunctional protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins. Schlacht A, et al. Traffic, 2013 Jun. PMID 23433073, Free PMC Article
    2. Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. Gupta GD, et al. PLoS One, 2009 Aug 26. PMID 19707569, Free PMC Article
    3. The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge. Zeledon C, et al. Cell Rep, 2019 Sep 17. PMID 31533044
    4. A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection. Glittenberg MT, et al. Dis Model Mech, 2022 May 1. PMID 35142345, Free PMC Article
    5. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Bernards A. Biochim Biophys Acta, 2003 Mar 17. PMID 12618308

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8243-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8922785..8925346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136580.2 → NP_610424.1  uncharacterized protein Dmel_CG8243 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7K6, Q8SWV3
      Related
      FBpp0087733
      Conserved Domains (2) summary
      COG5347
      Location:20 → 300
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
      pfam01412
      Location:18 → 132
      ArfGap; Putative GTPase activating protein for Arf
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7K6 A1Z7K6
    Q8SWV3 Q8SWV3

    Gene LinkOut

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