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    jvl javelin-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    jvlprovided by FlyBase
    Official Full Name
    javelin-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263929
    Locus tag
    Dmel_CG43162
    See related
    AllianceGenome:FB:FBgn0263929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.4; anon-WO0153538.5; CG33330; CG3563; CG43162; Dmel\CG43162; Jvl
    Old locus tag
    CG3563; Dmel_CG33330; Dmel_CG3563
    Summary
    Involved in several processes, including dorsal appendage formation; intracellular mRNA localization involved in anterior/posterior axis specification; and oogenesis. Located in microtubule cytoskeleton. Is expressed in egg chamber; larval apodeme; macrochaeta; nurse cell; and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See jvl in Genome Data Viewer
    Location:
    88D2-88D3; 3-56 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14741582..14795868)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10567304..10621590)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene effete Neighboring gene Senescence marker protein-30 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like. Amsalem S, et al. Mol Cell Biol, 2013 Nov. PMID 24019068, Free PMC Article
    2. Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles. Tilney LG, et al. Mol Biol Cell, 2003 Oct. PMID 14517310, Free PMC Article
    3. The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity. Baskar R, et al. FEBS J, 2019 Oct. PMID 31152621
    4. A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation. Otani T, et al. Development, 2015 Jul 1. PMID 26092846, Free PMC Article
    5. Drosophila javelin-like encodes a novel microtubule-associated protein and is required for mRNA localization during oogenesis. Dubin-Bar D, et al. Development, 2011 Nov. PMID 21989913

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results show that the microtubule plus-end tracking and stabilizing activities of Jvl are central for controlling cell polarity of oocytes and bristles
      Title: The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity.
    2. Spn-F mediates the interaction between Ik2 and Jvl to control Ik2 activity.
      Title: Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterior mRNA localization involved in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte localization involved in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in posterior mRNA localization involved in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    javelin-like
    Names
    CG43162-PA
    CG43162-PB
    CG43162-PC
    CG43162-PD
    CG43162-PE
    CG43162-PF
    CG43162-PG
    Javelin-Like
    javelinlike
    jvl-PA
    jvl-PB
    jvl-PC
    jvl-PD
    jvl-PE
    jvl-PF
    jvl-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14741582..14795868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142132.4 → NP_650389.2  javelin-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650389.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQF1, Q9VFG3
      Related
      FBpp0296970
      Conserved Domains (1) summary
      cl23720
      Location:428 → 555
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001260176.2 → NP_001247105.1  javelin-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247105.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K682
      Conserved Domains (1) summary
      cl23720
      Location:428 → 555
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_001260178.2 → NP_001247107.1  javelin-like, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6H8, D0IQF1
      Conserved Domains (1) summary
      cl23720
      Location:428 → 555
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. NM_001260177.2 → NP_001247106.1  javelin-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247106.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQF1, Q6NNB4
      Conserved Domains (1) summary
      cl23720
      Location:233 → 360
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. NM_001260179.2 → NP_001247108.1  javelin-like, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6X6, D0IQF1
      Conserved Domains (2) summary
      COG1340
      Location:250 → 359
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam05109
      Location:536 → 947
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    6. NM_001104323.3 → NP_001097793.1  javelin-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQF1, Q6NNB4
      Conserved Domains (1) summary
      cl23720
      Location:233 → 360
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    7. NM_206488.2 → NP_996210.1  javelin-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQF1, Q7KSJ6
      Conserved Domains (1) summary
      cl23720
      Location:234 → 361
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K682 A0A0B4K682
    A0A0B4K6H8 A0A0B4K6H8
    A0A0B4K6X6 A0A0B4K6X6
    Q6NNB4 Q6NNB4
    Q7KSJ6 Q7KSJ6
    Q960P5 Q960P5
    Q9VFG3 Q9VFG3

    Gene LinkOut

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