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    RyR Ryanodine receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49090, updated on 12-Dec-2024

    Summary

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    Official Symbol
    RyRprovided by FlyBase
    Official Full Name
    Ryanodine receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011286
    Locus tag
    Dmel_CG10844
    See related
    AllianceGenome:FB:FBgn0011286
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10844; D-RyR; Dmel\CG10844; DmRyR; DRR; dry; DRY; dRyr; dRyR; dya; l(2)k00424; l(2)k04913; Rya-44F; Rya-r4; rya-r44F; Rya-r44F; Rya-R44F; Rya-r76CD; ryr; Ryr; RYR; RyRs
    Summary
    Enables calcium channel activity. Involved in several processes, including heart contraction; regulation of hemocyte proliferation; and response to anesthetic. Predicted to be located in membrane. Is expressed in several structures, including adult brain; adult head; adult heart; larval muscle system; and muscle cell. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; congestive heart failure (multiple); hepatocellular carcinoma; intracranial vasospasm; and muscle tissue disease (multiple). Orthologous to human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RyR in Genome Data Viewer
    Location:
    44F1-44F2; 2-59 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8860364..8888097)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4747869..4775602)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sticks and stones Neighboring gene uncharacterized protein Neighboring gene Dynactin 2, p50 subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigation of the contribution of RyR target-site mutations in diamide resistance by CRISPR/Cas9 genome modification in Drosophila. Douris V, et al. Insect Biochem Mol Biol, 2017 Aug. PMID 28669775
    2. Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. Adkins AE, et al. Alcohol Clin Exp Res, 2017 May. PMID 28226201, Free PMC Article
    3. Molecular cloning of cDNA encoding a drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel. Xu X, et al. Biophys J, 2000 Mar. PMID 10692315, Free PMC Article
    4. Identification of a critical region in the Drosophila ryanodine receptor that confers sensitivity to diamide insecticides. Tao Y, et al. Insect Biochem Mol Biol, 2013 Sep. PMID 23806522
    5. Multiple target-site mutations occurring in lepidopterans confer resistance to diamide insecticides. Huang 黄镜梅 JM, et al. Insect Biochem Mol Biol, 2020 Jun. PMID 32243905

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of TRPA1 and RyR demonstrates that Ca(2+) signaling is required for oxidative stress-induced activation of the Ras/MAPK pathway, which in turns drives intestinal stem cell proliferation.
      Title: Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca(2+) signaling in the Drosophila midgut.
    2. The 46 aa segment of the Drosophila RyR C-terminus confers sensitivity to diamide insecticides.
      Title: Identification of a critical region in the Drosophila ryanodine receptor that confers sensitivity to diamide insecticides.
    3. Ryanodine receptors are an important mediator of immobilization by volatile anesthetics.
      Title: Drosophila ryanodine receptors mediate general anesthesia by halothane.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ryanodine-sensitive calcium-release channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables store-operated calcium channel activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in sarcoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ryanodine receptor
    Names
    CG10844-PA
    CG10844-PB
    CG10844-PC
    CG10844-PD
    CG10844-PE
    CG10844-PF
    CG10844-PG
    CG10844-PH
    CG10844-PI
    CG10844-PJ
    RyR-PA
    RyR-PB
    RyR-PC
    RyR-PD
    RyR-PE
    RyR-PF
    RyR-PG
    RyR-PH
    RyR-PI
    RyR-PJ
    RyanodineR
    ryanodine receptor 44F

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8860364..8888097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259280.1 → NP_001246209.1  ryanodine receptor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7U9
      Conserved Domains (11) summary
      smart00472
      Location:270 → 305
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 799
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1213
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4845 → 4965
      Ion_trans; Ion transport protein
      pfam01365
      Location:443 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:967 → 1057
      RyR; RyR domain
      pfam02815
      Location:211 → 392
      MIR; MIR domain
      pfam06459
      Location:4514 → 4757
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:4006 → 4119
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 202
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1518 → 1669
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    2. NM_001259277.1 → NP_001246206.1  ryanodine receptor, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K715
      Conserved Domains (11) summary
      smart00472
      Location:270 → 305
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 799
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1213
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4837 → 4957
      Ion_trans; Ion transport protein
      pfam01365
      Location:443 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:967 → 1057
      RyR; RyR domain
      pfam02815
      Location:211 → 392
      MIR; MIR domain
      pfam06459
      Location:4506 → 4749
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3998 → 4111
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 202
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1518 → 1669
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    3. NM_057645.3 → NP_476993.1  ryanodine receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24498
      Related
      FBpp0087718
      Conserved Domains (11) summary
      smart00472
      Location:270 → 305
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 799
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1213
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4849 → 4969
      Ion_trans; Ion transport protein
      pfam01365
      Location:443 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:967 → 1057
      RyR; RyR domain
      pfam02815
      Location:211 → 392
      MIR; MIR domain
      pfam06459
      Location:4518 → 4761
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:4010 → 4123
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 202
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1518 → 1669
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    4. NM_001259281.2 → NP_001246210.1  ryanodine receptor, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6T5
      Conserved Domains (11) summary
      smart00472
      Location:274 → 309
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:651 → 803
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1083 → 1217
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4852 → 4972
      Ion_trans; Ion transport protein
      pfam01365
      Location:447 → 640
      RYDR_ITPR; RIH domain
      pfam02026
      Location:971 → 1061
      RyR; RyR domain
      pfam02815
      Location:215 → 396
      MIR; MIR domain
      pfam06459
      Location:4521 → 4764
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:4013 → 4126
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 206
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1522 → 1673
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    5. NM_001259278.2 → NP_001246207.1  ryanodine receptor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K837
      Conserved Domains (11) summary
      smart00472
      Location:274 → 309
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:651 → 803
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1083 → 1217
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4839 → 4959
      Ion_trans; Ion transport protein
      pfam01365
      Location:447 → 640
      RYDR_ITPR; RIH domain
      pfam02026
      Location:971 → 1061
      RyR; RyR domain
      pfam02815
      Location:215 → 396
      MIR; MIR domain
      pfam06459
      Location:4508 → 4751
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:4000 → 4113
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 206
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1522 → 1673
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    6. NM_057643.4 → NP_476991.1  ryanodine receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476991.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24321, Q24498, Q24499, Q24500, Q24501, Q8MKS3, Q8MKS4, Q8MKS5, Q9V4Y7
      Related
      FBpp0087721
      Conserved Domains (11) summary
      smart00472
      Location:270 → 305
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 799
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1213
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4849 → 4969
      Ion_trans; Ion transport protein
      pfam01365
      Location:443 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:967 → 1057
      RyR; RyR domain
      pfam02815
      Location:211 → 392
      MIR; MIR domain
      pfam06459
      Location:4518 → 4761
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:4010 → 4123
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 202
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1518 → 1669
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    7. NM_001259279.2 → NP_001246208.1  ryanodine receptor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7K0
      Conserved Domains (11) summary
      smart00472
      Location:270 → 305
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 799
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1213
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4841 → 4961
      Ion_trans; Ion transport protein
      pfam01365
      Location:443 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:967 → 1057
      RyR; RyR domain
      pfam02815
      Location:211 → 392
      MIR; MIR domain
      pfam06459
      Location:4510 → 4753
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:4002 → 4115
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 202
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1518 → 1669
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    8. NM_057644.4 → NP_476992.1  ryanodine receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24498
      Related
      FBpp0087719
      Conserved Domains (11) summary
      smart00472
      Location:270 → 305
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 799
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1213
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4835 → 4955
      Ion_trans; Ion transport protein
      pfam01365
      Location:443 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:967 → 1057
      RyR; RyR domain
      pfam02815
      Location:211 → 392
      MIR; MIR domain
      pfam06459
      Location:4504 → 4747
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3996 → 4109
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 202
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1518 → 1669
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    9. NM_057646.4 → NP_476994.1  ryanodine receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24498
      Related
      FBpp0087720
      Conserved Domains (11) summary
      smart00472
      Location:270 → 305
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 799
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1213
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4835 → 4955
      Ion_trans; Ion transport protein
      pfam01365
      Location:443 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:967 → 1057
      RyR; RyR domain
      pfam02815
      Location:211 → 392
      MIR; MIR domain
      pfam06459
      Location:4504 → 4747
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:3996 → 4109
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 202
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1518 → 1669
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

    10. NM_001259282.2 → NP_001246211.1  ryanodine receptor, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K719
      Conserved Domains (11) summary
      smart00472
      Location:270 → 305
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647 → 799
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:1079 → 1213
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      pfam00520
      Location:4856 → 4976
      Ion_trans; Ion transport protein
      pfam01365
      Location:443 → 636
      RYDR_ITPR; RIH domain
      pfam02026
      Location:967 → 1057
      RyR; RyR domain
      pfam02815
      Location:211 → 392
      MIR; MIR domain
      pfam06459
      Location:4525 → 4768
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:4017 → 4130
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:11 → 202
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      cd12879
      Location:1518 → 1669
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6T5 A0A0B4K6T5
    A0A0B4K715 A0A0B4K715
    A0A0B4K719 A0A0B4K719
    A0A0B4K7K0 A0A0B4K7K0
    A0A0B4K7U9 A0A0B4K7U9
    A0A0B4K837 A0A0B4K837
    Q24498.3 Q24498

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