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    squ squash [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    squprovided by FlyBase
    Official Full Name
    squashprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267347
    Locus tag
    Dmel_CG4711
    See related
    AllianceGenome:FB:FBgn0267347
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atg; CG4711; Dmel\CG4711; mat(2)cell-A; mat(2)cellHK35; SQU
    Summary
    Involved in regulatory ncRNA-mediated gene silencing. Located in P granule. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See squ in Genome Data Viewer
    Location:
    36A10-36A10; 2-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16680054..16681653)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16680054..16681653)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Transient receptor potential cation channel gamma Neighboring gene mir-2497 stem loop Neighboring gene hermaphrodite Neighboring gene uncharacterized protein Neighboring gene grapes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44975

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity. Fogarty P, et al. Curr Biol, 1997 Jun 1. PMID 9197245
    2. The epigenetic trans-silencing effect in Drosophila involves maternally-transmitted small RNAs whose production depends on the piRNA pathway and HP1. Todeschini AL, et al. PLoS One, 2010 Jun 14. PMID 20559422, Free PMC Article
    3. Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila. Haase AD, et al. Genes Dev, 2010 Nov 15. PMID 20966049, Free PMC Article
    4. Mutations to the piRNA pathway component aubergine enhance meiotic drive of segregation distorter in Drosophila melanogaster. Gell SL, et al. Genetics, 2013 Mar. PMID 23267055, Free PMC Article
    5. Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins. Andress A, et al. J Cell Biol, 2016 Apr 25. PMID 27091448, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in dorsal appendage formation HMP PubMed 
    involved_in oogenesis HMP PubMed 
    involved_in oogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    squash
    Names
    CG4711-PA
    CG4711-PB
    CG4711-PC
    adjacent-to-grapes
    squ-PA
    squ-PB
    squ-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16680054..16681653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206000.4 → NP_995722.1  squash, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0CPT7, L0CRL5, Q7KT57

    2. NM_001273578.1 → NP_001260507.1  squash, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0CPT7, L0CRL5, Q7KT57

    3. NM_001259115.2 → NP_001246044.1  squash, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246044.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0CPT7, L0CRL5, Q7KT57
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KT57 Q7KT57

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