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    Marf1 Meiosis regulator and mRNA stability factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49895, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Marf1provided by FlyBase
    Official Full Name
    Meiosis regulator and mRNA stability factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039972
    Locus tag
    Dmel_CG17018
    See related
    AllianceGenome:FB:FBgn0039972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE40762; CG17018; CG17410; Dmel\CG17018; LKAP; MARF1
    Summary
    Enables CCR4-NOT complex binding activity and protein-RNA adaptor activity. Involved in 3'-UTR-mediated mRNA destabilization and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Located in cytosol and nucleus. Is expressed in organism. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Marf1 in Genome Data Viewer
    Location:
    40F7-40F7; 2-54 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22308755..22368796)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22308755..22368796)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Tif-IA Neighboring gene Ribosomal protein L21 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR46268 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuroprotective potential of flavonoid rich Ascophyllum nodosum (FRAN) fraction from the brown seaweed on an Aβ(42) induced Alzheimer's model of Drosophila. Chauhan BS, et al. Phytomedicine, 2022 Jan. PMID 34906893
    2. The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Jeske M, et al. Genes Dev, 2017 May 1. PMID 28536148, Free PMC Article
    3. The developmental proteome of Drosophila melanogaster. Casas-Vila N, et al. Genome Res, 2017 Jul. PMID 28381612, Free PMC Article
    4. The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation. Peng Y, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35699205, Free PMC Article
    5. Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1. Liu W, et al. Cell Death Differ, 2020 Jun. PMID 31907391, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dMarf1 translationally represses nos by binding to its mRNA.
      Title: Drosophila MARF1 ensures proper oocyte maturation by regulating nanos expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22311178-22311665 mobile_element_type = transposon:INE-1{}2128
    • Loc: 22314315-22314808 mobile_element_type = transposon:gypsy4{}2661
    • Loc: 22314971-22315275 mobile_element_type = transposon:INE-1{}2130
    • Loc: 22315673-22318155 mobile_element_type = transposon:frogger{}558
    • Loc: 22321993-22322176 mobile_element_type = transposon:INE-1{}2132
    • Loc: 22322856-22323070 mobile_element_type = transposon:gypsy6{}559
    • Loc: 22325984-22326373 mobile_element_type = transposon:INE-1{}2133
    • Loc: 22327585-22327681 mobile_element_type = transposon:Cr1a{}2556
    • Loc: 22329230-22337869 mobile_element_type = transposon:invader5{}1644
    • Loc: 22341330-22341383 mobile_element_type = transposon:diver2{}2646
    • Loc: 22342755-22342967 mobile_element_type = transposon:G4{}570
    • Loc: 22342974-22343153 mobile_element_type = transposon:Doc3{}Marf1[571]
    • Loc: 22346693-22348202 mobile_element_type = transposon:X{}572
    • Loc: 22352231-22352486 mobile_element_type = transposon:INE-1{}2149
    • Loc: 22353277-22353852 mobile_element_type = transposon:Cr1a{}2559
    • Loc: 22355883-22356416 mobile_element_type = transposon:Idefix{}2603

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CCR4-NOT complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-RNA adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiosis regulator and mRNA stability factor 1
    Names
    CG17018-PA
    CG17018-PC
    CG17018-PD
    CG17018-PE
    CG17018-PF
    Marf1-PA
    Marf1-PC
    Marf1-PD
    Marf1-PE
    Marf1-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22308755..22368796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259203.2 → NP_001246132.1  meiosis regulator and mRNA stability factor 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W5Y4
      Conserved Domains (3) summary
      cd08824
      Location:772 → 839
      LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
      cl14879
      Location:527 → 598
      LabA_like_C; C-terminal domain of LabA_like proteins
      cl17169
      Location:220 → 304
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_165414.2 → NP_724393.2  meiosis regulator and mRNA stability factor 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724393.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KWH0
      Related
      FBpp0085310
      Conserved Domains (3) summary
      cd08824
      Location:794 → 861
      LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
      cl14879
      Location:549 → 620
      LabA_like_C; C-terminal domain of LabA_like proteins
      cl17169
      Location:242 → 326
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_165415.2 → NP_724394.2  meiosis regulator and mRNA stability factor 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724394.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KWG9
      Related
      FBpp0085311
      Conserved Domains (3) summary
      cd08824
      Location:805 → 872
      LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
      cl14879
      Location:560 → 631
      LabA_like_C; C-terminal domain of LabA_like proteins
      cl17169
      Location:253 → 337
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_165413.2 → NP_724392.1  meiosis regulator and mRNA stability factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W5Y4
      Related
      FBpp0085309
      Conserved Domains (3) summary
      cd08824
      Location:772 → 839
      LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
      cl14879
      Location:527 → 598
      LabA_like_C; C-terminal domain of LabA_like proteins
      cl17169
      Location:220 → 304
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001259204.1 → NP_001246133.1  meiosis regulator and mRNA stability factor 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KWG9
      Conserved Domains (3) summary
      cd08824
      Location:805 → 872
      LOTUS; LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7
      cl14879
      Location:560 → 631
      LabA_like_C; C-terminal domain of LabA_like proteins
      cl17169
      Location:253 → 337
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KWG9 Q7KWG9
    Q7KWH0 Q7KWH0
    Q8SXS3 Q8SXS3
    Q9W5Y4 Q9W5Y4

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