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    rhea rhea [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rheaprovided by FlyBase
    Official Full Name
    rheaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260442
    Locus tag
    Dmel_CG6831
    See related
    AllianceGenome:FB:FBgn0260442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6831; CT21159; Dmel\CG6831; Rhea; talin; Talin; tendrils; Tln
    Old locus tag
    CG6831
    Summary
    Enables integrin binding activity. Involved in several processes, including apposition of dorsal and ventral imaginal disc-derived wing surfaces; border follicle cell migration; and germ-band shortening. Located in focal adhesion. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval midgut primordium; and muscle attachment site. Orthologous to several human genes including TLN2 (talin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rhea in Genome Data Viewer
    Location:
    66D6-66D7; 3-26 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8545001..8574409)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8538101..8567509)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene fear-of-intimacy Neighboring gene ergic53 Neighboring gene long non-coding RNA:CR43910 Neighboring gene mir-190 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Negative elongation factor E Neighboring gene Ribosomal protein L14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Talin's second persona. Tepass U, et al. Nat Cell Biol, 2005 May. PMID 15867924
    2. Gene duplication and functional divergence during evolution of the cytoskeletal linker protein talin. Senetar MA, et al. Gene, 2005 Dec 5. PMID 16216449
    3. Talin - the master of integrin adhesions. Klapholz B, et al. J Cell Sci, 2017 Aug 1. PMID 28701514
    4. Crystal structure of the talin integrin binding domain 2. Cheung TY, et al. J Mol Biol, 2009 Apr 10. PMID 19340939
    5. Evolution at the subgene level: domain rearrangements in the Drosophila phylogeny. Wu YC, et al. Mol Biol Evol, 2012 Feb. PMID 21900599, Free PMC Article

    See all (234) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.
      Title: The actin binding sites of talin have both distinct and complementary roles in cell-ECM adhesion.
    2. Results demonstrate that Talin phosphorylation by Slik plays an important role in fine-tuning Talin recruitment to integrin adhesion sites and maintaining muscle attachment.
      Title: Slik phosphorylation of Talin T152 is crucial for proper Talin recruitment and maintenance of muscle attachment in Drosophila.
    3. Demonstrate a continuous requirement for Talin during heart growth to maintain one-to-one apposition of myofibril ends between cardiomyocytes. Retracted myofibrils cannot regenerate appositions to adjacent cells after restoration of Talin expression.
      Title: Talin Is Required Continuously for Cardiomyocyte Remodeling during Heart Growth in Drosophila.
    4. The different arrangements of the talin molecule relative to integrins suggest that talin is able to sense different force vectors, either parallel or perpendicular to the membrane.
      Title: Alternative mechanisms for talin to mediate integrin function.
    5. Talin provides instructive cues to position the luminal domain and coordinate the actin cytoskeleton during Drosophila heart lumen development
      Title: Talin is required to position and expand the luminal domain of the Drosophila heart tube.
    6. We propose that the talin head domain is essential for regulating integrin avidity in Drosophila and that this is crucial for integrin-mediated adhesion during animal development.
      Title: The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.
    7. Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitor
      Title: Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors.
    8. talin integrin binding sites reinforce integrin attachment to the extracellular matrix and reinforce the link between integrins and the intracellular adhesion complex
      Title: In vivo functional analysis reveals specific roles for the integrin-binding sites of talin.
    9. Data show that introduction of mutations that reduced actin binding in vitro into the isolated C-terminal Talin-ABD impaired actin binding in vivo.
      Title: Distinct developmental roles for direct and indirect talin-mediated linkage to actin.
    10. crystal structure of the talin IBS2 domain, which forms a five-helix bundle
      Title: Crystal structure of the talin integrin binding domain 2.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cardiac muscle cell-cardiac muscle cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lumen formation, open tracheal system HMP PubMed 
    involved_in maintenance of epithelial integrity, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal branching, open tracheal system HMP PubMed 
    Component Evidence Code Pubs
    located_in Z disc HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rhea
    Names
    CG6831-PB
    CG6831-PC
    CG6831-PD
    CG6831-PE
    CG6831-PF
    CG6831-PG
    CG6831-PH
    CG6831-PI
    rhea-PB
    rhea-PC
    rhea-PD
    rhea-PE
    rhea-PF
    rhea-PG
    rhea-PH
    rhea-PI
    talin
    tendrils

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8545001..8574409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259745.2 → NP_001246674.1  rhea, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSL8
      Conserved Domains (12) summary
      cd12150
      Location:1661 → 1832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89 → 322
      B41; Band 4.1 homologues
      COG0840
      Location:1694 → 2005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318 → 409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215 → 322
      FERM_M; FERM central domain
      pfam01044
      Location:874 → 1035
      Vinculin; Vinculin family
      pfam01608
      Location:2392 → 2534
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:1859 → 1982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510 → 668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686 → 778
      I_LWEQ; I/LWEQ domain

    2. NM_001274658.1 → NP_001261587.1  rhea, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBW9
      Conserved Domains (12) summary
      cd12150
      Location:1640 → 1811
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89 → 322
      B41; Band 4.1 homologues
      COG0840
      Location:1673 → 1984
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318 → 409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215 → 322
      FERM_M; FERM central domain
      pfam01044
      Location:853 → 1014
      Vinculin; Vinculin family
      pfam01608
      Location:2371 → 2513
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:1838 → 1961
      VBS; Vinculin Binding Site
      pfam09141
      Location:489 → 647
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:665 → 757
      I_LWEQ; I/LWEQ domain

    3. NM_001259746.2 → NP_001246675.1  rhea, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDM3
      Conserved Domains (11) summary
      cd12150
      Location:1661 → 1832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89 → 322
      B41; Band 4.1 homologues
      COG0840
      Location:1694 → 2005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318 → 409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215 → 322
      FERM_M; FERM central domain
      pfam01044
      Location:874 → 1035
      Vinculin; Vinculin family
      pfam08913
      Location:1859 → 1982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510 → 668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686 → 778
      I_LWEQ; I/LWEQ domain

    4. NM_001274659.1 → NP_001261588.1  rhea, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEJ8
      Conserved Domains (12) summary
      cd12150
      Location:1661 → 1832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89 → 322
      B41; Band 4.1 homologues
      COG0840
      Location:1694 → 2005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318 → 409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215 → 322
      FERM_M; FERM central domain
      pfam01044
      Location:874 → 1035
      Vinculin; Vinculin family
      pfam01608
      Location:2392 → 2534
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:1859 → 1982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510 → 668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686 → 778
      I_LWEQ; I/LWEQ domain

    5. NM_001274660.1 → NP_001261589.1  rhea, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF06
      Conserved Domains (5) summary
      smart00295
      Location:89 → 322
      B41; Band 4.1 homologues
      cd10569
      Location:318 → 409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215 → 322
      FERM_M; FERM central domain
      pfam09379
      Location:92 → 147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM

    6. NM_001259747.2 → NP_001246676.1  rhea, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDM3
      Conserved Domains (11) summary
      cd12150
      Location:1661 → 1832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89 → 322
      B41; Band 4.1 homologues
      COG0840
      Location:1694 → 2005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318 → 409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215 → 322
      FERM_M; FERM central domain
      pfam01044
      Location:874 → 1035
      Vinculin; Vinculin family
      pfam08913
      Location:1859 → 1982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510 → 668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686 → 778
      I_LWEQ; I/LWEQ domain

    7. NM_001274657.1 → NP_001261586.1  rhea, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSL8
      Conserved Domains (12) summary
      cd12150
      Location:1661 → 1832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89 → 322
      B41; Band 4.1 homologues
      COG0840
      Location:1694 → 2005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318 → 409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215 → 322
      FERM_M; FERM central domain
      pfam01044
      Location:874 → 1035
      Vinculin; Vinculin family
      pfam01608
      Location:2392 → 2534
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:1859 → 1982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510 → 668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686 → 778
      I_LWEQ; I/LWEQ domain

    8. NM_139981.4 → NP_648238.1  rhea, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSL8
      Related
      FBpp0305318
      Conserved Domains (12) summary
      cd12150
      Location:1661 → 1832
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:89 → 322
      B41; Band 4.1 homologues
      COG0840
      Location:1694 → 2005
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd10569
      Location:318 → 409
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:215 → 322
      FERM_M; FERM central domain
      pfam01044
      Location:874 → 1035
      Vinculin; Vinculin family
      pfam01608
      Location:2392 → 2534
      I_LWEQ; I/LWEQ domain
      pfam08913
      Location:1859 → 1982
      VBS; Vinculin Binding Site
      pfam09141
      Location:510 → 668
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92 → 147
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:4 → 85
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:686 → 778
      I_LWEQ; I/LWEQ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDM3 M9NDM3
    M9PBW9 M9PBW9
    M9PEJ8 M9PEJ8
    M9PF06 M9PF06
    Q960C2 Q960C2
    Q9VSL8 Q9VSL8

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