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    Fign fidgetin [ Mus musculus (house mouse) ]

    Gene ID: 60344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fignprovided by MGI
    Official Full Name
    fidgetinprovided by MGI
    Primary source
    MGI:MGI:1890647
    See related
    Ensembl:ENSMUSG00000075324 AllianceGenome:MGI:1890647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    fi; Fgn; fidget
    Summary
    Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Acts upstream of or within locomotory behavior. Located in nuclear matrix. Is expressed in central nervous system and heart. Orthologous to human FIGN (fidgetin, microtubule severing factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 2.5), CNS E11.5 (RPKM 2.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fign in Genome Data Viewer
    Location:
    2 C1.3; 2 37.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (63801852..63928382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (63971508..64098038, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23503 Neighboring gene STARR-seq mESC enhancer starr_04653 Neighboring gene predicted gene 8541 Neighboring gene STARR-seq mESC enhancer starr_04654 Neighboring gene STARR-seq mESC enhancer starr_04655 Neighboring gene STARR-seq mESC enhancer starr_04658 Neighboring gene STARR-seq mESC enhancer starr_04659 Neighboring gene STARR-seq mESC enhancer starr_04660 Neighboring gene STARR-seq mESC enhancer starr_04661 Neighboring gene predicted gene 13575 Neighboring gene STARR-seq mESC enhancer starr_04663 Neighboring gene Parkinson disease 7 domain containing 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism. Matamoros AJ, et al. J Neurosci, 2019 Mar 13. PMID 30647150, Free PMC Article
    2. The position of fidget in linkage group V of the house mouse. CARTER TC. J Genet, 1951 Jan. PMID 24539707
    3. The cell cycle and retinal histogenesis fidget mutant mice. Konyukhov BV, et al. Dev Biol, 1976 Nov. PMID 1001817
    4. Functional characterization of fidgetin, an AAA-family protein mutated in fidget mice. Yang Y, et al. Exp Cell Res, 2005 Mar 10. PMID 15707573
    5. Reduction in recombination due to a deletion in a colony of wild mice. Wallace ME. J Hered, 1972 Sep-Oct. PMID 4644332

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of fidgetin improves regeneration of injured axons by a microtubule-based mechanism.
      Title: Knockdown of Fidgetin Improves Regeneration of Injured Axons by a Microtubule-Based Mechanism.
    2. fidgetin co-localized with endogenous AKAP95 in the nuclear matrix; AKAP95 mutant mice are surprisingly viable with no overt phenotype;mice carrying both Akap95 and fidget mutations die soon after birth due to cleft palate
      Title: Interaction between fidgetin and protein kinase A-anchoring protein AKAP95 is critical for palatogenesis in the mouse.
    3. Functional characterization of fidgetin.
      Title: Functional characterization of fidgetin, an AAA-family protein mutated in fidget mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fidgetin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267846.1 → NP_001254775.1  fidgetin isoform 2

      See identical proteins and their annotated locations for NP_001254775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' coding region, which results in a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL928553, BC059266
      UniProtKB/Swiss-Prot
      Q9ERZ6
      Conserved Domains (3) summary
      TIGR01242
      Location:378 → 725
      26Sp45; 26S proteasome subunit P45 family
      pfam00004
      Location:511 → 641
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:712 → 745
      Vps4_C; Vps4 C terminal oligomerization domain

    2. NM_001267847.1 → NP_001254776.1  fidgetin isoform 2

      See identical proteins and their annotated locations for NP_001254776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate segment in the 5' coding region, which results in a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK143787, AK164536, AL928553, BC059266
      UniProtKB/Swiss-Prot
      Q9ERZ6
      Conserved Domains (3) summary
      TIGR01242
      Location:378 → 725
      26Sp45; 26S proteasome subunit P45 family
      pfam00004
      Location:511 → 641
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:712 → 745
      Vps4_C; Vps4 C terminal oligomerization domain

    3. NM_021716.5 → NP_068362.1  fidgetin isoform 1

      See identical proteins and their annotated locations for NP_068362.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK163474, AL928553, BC059266
      Consensus CDS
      CCDS16070.1
      UniProtKB/Swiss-Prot
      Q3TPB0, Q3UP57, Q6PCM0, Q9ERZ6
      Related
      ENSMUSP00000122855.3, ENSMUST00000131615.9
      Conserved Domains (3) summary
      TIGR01242
      Location:389 → 736
      26Sp45; 26S proteasome subunit P45 family
      pfam00004
      Location:522 → 652
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:723 → 756
      Vps4_C; Vps4 C terminal oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      63801852..63928382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERZ6.1 GenPept UniProtKB/Swiss-Prot:Q9ERZ6

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