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    disl-2 DIS3-like exonuclease 2 [ Caenorhabditis elegans ]

    Gene ID: 175748, updated on 9-Dec-2024

    Summary

    Official Symbol
    disl-2
    Official Full Name
    DIS3-like exonuclease 2
    Primary source
    WormBase:WBGene00018612
    Locus tag
    CELE_F48E8.6
    See related
    AllianceGenome:WB:WBGene00018612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity. Involved in regulation of cell fate specification and regulation of development, heterochronic. Predicted to be located in cytoplasm. Predicted to be active in P-body. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See disl-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (5443167..5446506)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene NET domain-containing protein;Protein kinase domain-containing protein Neighboring gene DM2 domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Hsp20/alpha crystallin family protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity  
    enables 3'-5'-RNA exonuclease activity  
    enables RNA binding  
    enables RNA nuclease activity  
    enables exonuclease activity  
    enables metal ion binding  
    Component Evidence Code Pubs
    is_active_in P-body  
    located_in P-body  
    located_in cytoplasm  

    General protein information

    Preferred Names
    DIS3-like exonuclease 2
    NP_498160.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5443167..5446506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065759.7 → NP_498160.2  DIS3-like exonuclease 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498160.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09568
      Conserved Domains (2) summary
      COG0557
      Location:76 → 770
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:333 → 685
      RNB; RNB domain
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