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    Y62E10A.13 Phosphoserine phosphatase [ Caenorhabditis elegans ]

    Gene ID: 178304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y62E10A.13
    Official Full Name
    Phosphoserine phosphatase
    Primary source
    WormBase:WBGene00013379
    Locus tag
    CELE_Y62E10A.13
    See related
    AllianceGenome:WB:WBGene00013379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-phosphoserine phosphatase activity and magnesium ion binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in head and intestine. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y62E10A.13 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (13389146..13399053, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 9 Neighboring gene Guanine nucleotide exchange factor MSS4 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene MEiosis-to-MItosis transition associated Neighboring gene CYtochrome P450 family Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-phosphoserine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-phosphoserine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-serine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Phosphoserine phosphatase
    NP_001041052.2
    • Confirmed by transcript evidence
    NP_001293892.1
    • Confirmed by transcript evidence
    NP_001293893.1
    • Confirmed by transcript evidence
    NP_001293894.1
    • Confirmed by transcript evidence
    NP_001293895.1
    • Confirmed by transcript evidence
    NP_001359637.1
    • Confirmed by transcript evidence
    NP_502580.2
    • Confirmed by transcript evidence
    NP_502581.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13389146..13399053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306966.2 → NP_001293895.1  Phosphoserine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACH4
      Conserved Domains (2) summary
      PLN02954
      Location:31 → 254
      PLN02954; phosphoserine phosphatase
      pfam00702
      Location:41 → 216
      Hydrolase; haloacid dehalogenase-like hydrolase

    2. NM_070179.7 → NP_502580.2  Phosphoserine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502580.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1W6
      Conserved Domains (2) summary
      PLN02954
      Location:44 → 267
      PLN02954; phosphoserine phosphatase
      pfam00702
      Location:54 → 229
      Hydrolase; haloacid dehalogenase-like hydrolase

    3. NM_070180.4 → NP_502581.2  Phosphoserine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502581.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1W7
      Conserved Domains (2) summary
      PLN02954
      Location:47 → 270
      PLN02954; phosphoserine phosphatase
      pfam00702
      Location:57 → 232
      Hydrolase; haloacid dehalogenase-like hydrolase

    4. NM_001372954.2 → NP_001359637.1  Phosphoserine phosphatase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Q10
      Conserved Domains (1) summary
      cd04309
      Location:41 → 248
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    5. NM_001306965.3 → NP_001293894.1  Phosphoserine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ADS3
      Conserved Domains (2) summary
      PLN02954
      Location:53 → 276
      PLN02954; phosphoserine phosphatase
      pfam00702
      Location:63 → 238
      Hydrolase; haloacid dehalogenase-like hydrolase

    6. NM_001306963.3 → NP_001293892.1  Phosphoserine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AKN1
      Conserved Domains (2) summary
      PLN02954
      Location:47 → 272
      PLN02954; phosphoserine phosphatase
      pfam00702
      Location:57 → 234
      Hydrolase; haloacid dehalogenase-like hydrolase

    7. NM_001306964.3 → NP_001293893.1  Phosphoserine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACK7
      Conserved Domains (2) summary
      PLN02954
      Location:53 → 278
      PLN02954; phosphoserine phosphatase
      pfam00702
      Location:63 → 240
      Hydrolase; haloacid dehalogenase-like hydrolase

    8. NM_001047587.4 → NP_001041052.2  Phosphoserine phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041052.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQB6
      Conserved Domains (1) summary
      cl21460
      Location:2 → 57
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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