sma-1 Spectrin beta chain [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sma-1
Official Full Name: Spectrin beta chain
Primary source: WormBase:WBGene00004855
Locus tag: CELE_R31.1
See related: AllianceGenome:WB:WBGene00004855
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity. Involved in several processes, including nematode pharyngeal gland morphogenesis; nematode pharynx development; and positive regulation of cell size. Located in apical plasma membrane; cytoplasm; and nucleus. Is expressed in several structures, including excretory cell; hermaphrodite gonad; neurons; pharynx; and vulval cell. Orthologous to human SPTBN5 (spectrin beta, non-erythrocytic 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sma-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 18

Sequence:: Chromosome: V; NC_003283.11 (11899449..11916623)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the spectrin cytoskeleton composed of SPC-1/alpha-spectrin, UNC-70/beta-spectrin, and SMA-1/beta heavy-spectrin as required for contractility and actin organization in the myoepithelial cells of the C. elegans spermathecal, were identified.
Title: Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca.
plays a dynamic role in converting changes in actin organization into changes in epithelial cell shape during C. elegans embryogenesis.
Title: SMA-1 spectrin has essential roles in epithelial cell sheet morphogenesis in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R31.1 (e-PCR)
- UniSTS:305698

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in organelle	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Spectrin beta chain

NP_001129903.1

Confirmed by transcript evidence

NP_001256382.1

Confirmed by transcript evidence

NP_001256383.1

Confirmed by transcript evidence

NP_001360523.1

Confirmed by transcript evidence

NP_001380250.1

Confirmed by transcript evidence

NP_741632.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11899449..11916623

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171544.7 → NP_741632.2 Spectrin beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741632.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EFW3

Conserved Domains (7) summary

pfam05483
Location:1967 → 2724

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:1453 → 1553

SPEC; Spectrin repeats

smart00326
Location:928 → 979

SH3; Src homology 3 domains

cd00014
Location:276 → 379

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:1770 → 1980

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:3780 → 3883

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:3780 → 3881

PH; PH domain
NM_001373124.2 → NP_001360523.1 Spectrin beta chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WUT8

Conserved Domains (5) summary

smart00150
Location:1453 → 1553

SPEC; Spectrin repeats

smart00326
Location:928 → 979

SH3; Src homology 3 domains

COG5069
Location:155 → 642

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:1770 → 1980

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:3780 → 3883

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
NM_001269454.3 → NP_001256383.1 Spectrin beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256383.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBH3

Conserved Domains (6) summary

smart00150
Location:1350 → 1450

SPEC; Spectrin repeats

smart00326
Location:825 → 876

SH3; Src homology 3 domains

cd00014
Location:173 → 276

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:1667 → 1877

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:3677 → 3780

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:3677 → 3778

PH; PH domain
NM_001136431.4 → NP_001129903.1 Spectrin beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129903.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EC35

Conserved Domains (7) summary

pfam05483
Location:1864 → 2621

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:1350 → 1450

SPEC; Spectrin repeats

smart00326
Location:825 → 876

SH3; Src homology 3 domains

cd00014
Location:173 → 276

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:1667 → 1877

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:3677 → 3780

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:3677 → 3778

PH; PH domain
NM_001269453.3 → NP_001256382.1 Spectrin beta chain [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256382.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EG97

Conserved Domains (7) summary

pfam05483
Location:1781 → 2538

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:1267 → 1367

SPEC; Spectrin repeats

smart00326
Location:742 → 793

SH3; Src homology 3 domains

cd00014
Location:90 → 193

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:1584 → 1794

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:3594 → 3697

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

pfam00169
Location:3594 → 3695

PH; PH domain
NM_001392621.1 → NP_001380250.1 Spectrin beta chain [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WVF0

Conserved Domains (6) summary

smart00150
Location:1267 → 1367

SPEC; Spectrin repeats

smart00326
Location:742 → 793

SH3; Src homology 3 domains

COG5069
Location:2 → 456

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:1584 → 1794

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd10571
Location:3594 → 3697

PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

cd21194
Location:88 → 192

CH_beta_spectrin_rpt2; second calponin homology (CH) domain found in the beta spectrin family