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    uig-1 PH domain-containing protein;Protein vav [ Caenorhabditis elegans ]

    Gene ID: 179808, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uig-1
    Official Full Name
    PH domain-containing protein;Protein vav
    Primary source
    WormBase:WBGene00009337
    Locus tag
    CELE_F32F2.1
    See related
    AllianceGenome:WB:WBGene00009337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein domain specific binding activity. Involved in regulation of engulfment of apoptotic cell. Located in striated muscle dense body. Is expressed in several structures, including excretory cell; intestine; neurons; non-striated muscle; and reproductive system. Orthologous to several human genes including PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See uig-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    18
    Sequence:
    Chromosome: V; NC_003283.11 (13273157..13295978, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Alpha/beta hydrolase Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HutD family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene YkgJ family cysteine cluster protein Neighboring gene Homeobox domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The UIG-1/CDC-42 guanine nucleotide exchange factor acts in parallel to CED-10/Rac1 during axon outgrowth in Caenorhabditis elegans. Cao W, et al. Small GTPases, 2021 Jan. PMID 31042115, Free PMC Article
    2. Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. elegans. Neukomm LJ, et al. Cell Death Differ, 2014 Jun. PMID 24632947, Free PMC Article
    3. ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration. Lecroisey C, et al. Mol Biol Cell, 2013 Apr. PMID 23427270, Free PMC Article
    4. Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle. Qadota H, et al. Mol Biol Cell, 2007 Nov. PMID 17761533, Free PMC Article
    5. Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure. Hikita T, et al. Biochem Biophys Res Commun, 2005 Sep 16. PMID 16055082

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UIG-1, a DH/PH domain containing protein, links a PAT-3/UNC-112 complex to the CDC-42 signaling pathway during muscle formation.
      Title: Identification of a novel Cdc42 GEF that is localized to the PAT-3-mediated adhesive structure.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of engulfment of apoptotic cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PH domain-containing protein;Protein vav
    NP_001256488.1
    • Partially confirmed by transcript evidence
    NP_001256489.1
    • Confirmed by transcript evidence
    NP_001256492.1
    • Confirmed by transcript evidence
    NP_001256493.1
    • Confirmed by transcript evidence
    NP_001256494.1
    • Confirmed by transcript evidence
    NP_001256495.1
    • Confirmed by transcript evidence
    NP_001366647.1
    • Confirmed by transcript evidence
    NP_001367249.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13273157..13295978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380798.1 → NP_001366647.1  PH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXM9
      Conserved Domains (2) summary
      smart00325
      Location:227 → 405
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:386 → 537
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    2. NM_001269564.4 → NP_001256493.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256493.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UBJ0
      Conserved Domains (1) summary
      cl17171
      Location:1 → 73
      PH-like; Pleckstrin homology-like domain

    3. NM_001380797.1 → NP_001367249.1  PH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EER5
      Conserved Domains (2) summary
      smart00325
      Location:260 → 438
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:419 → 570
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    4. NM_001269560.3 → NP_001256489.1  Protein vav [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF62
      Conserved Domains (2) summary
      smart00325
      Location:280 → 458
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:439 → 590
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    5. NM_001269559.3 → NP_001256488.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256488.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6GUP8
      Conserved Domains (2) summary
      smart00325
      Location:266 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:425 → 576
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    6. NM_001269563.3 → NP_001256492.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4YWB8
      Conserved Domains (2) summary
      smart00325
      Location:83 → 261
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13243
      Location:242 → 393
      PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain

    7. NM_001269565.3 → NP_001256494.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256494.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4YWB9

    8. NM_001269566.3 → NP_001256495.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256495.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4YWC0
    Nucleotide Protein
    Heading Accession and Version

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