grdn-1 Girdin homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: grdn-1
Official Full Name: Girdin homolog
Primary source: WormBase:WBGene00013082
Locus tag: CELE_Y51A2D.15
See related: AllianceGenome:WB:WBGene00013082
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dynein light intermediate chain binding activity and microtubule binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell projection organization; and positive regulation of dendrite extension. Located in centriole and ciliary basal body. Is expressed in sensory neurons. Human ortholog(s) of this gene implicated in hydrocephalus and spinocerebellar ataxia type 40. Orthologous to several human genes including CCDC88A (coiled-coil domain containing 88A) and CCDC88C (coiled-coil domain containing 88C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See grdn-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 20

Sequence:: Chromosome: V; NC_003283.11 (18592748..18614135)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans.
Title: GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans.
dendrite development in C elegans requires the adhesion protein SAX-7/L1CAM and the cytoplasmic protein GRDN-1/CCDC88C to anchor dendrite endings at the nose
Title: Dendrites with specialized glial attachments develop by retrograde extension using SAX-7 and GRDN-1.
C. elegans Girdin also regulates localization of the apical junction component AJM-1, suggesting that in nematodes Girdin may position BBs via rootletin- and AJM-1-dependent anchoring to the cytoskeleton and plasma membrane, respectively. Together, our results describe a conserved role for Girdin in BB positioning and ciliogenesis
Title: A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y51A2D.16 (e-PCR)
- UniSTS:312873

Y51A2D.15 (e-PCR)
- UniSTS:316213

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in amphid sensory organ dendrite retrograde extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ciliary basal body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ciliary transition zone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to ciliary transition zone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Girdin homolog

NP_001256816.1

Confirmed by transcript evidence

NP_001256818.1

Confirmed by transcript evidence

NP_001359512.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

18592748..18614135

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269887.4 → NP_001256816.1 Girdin homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256816.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F3Y5P4, F3Y5P5, Q9XXR1

Conserved Domains (1) summary

cl25732
Location:281 → 1083

SMC_N; RecF/RecN/SMC N terminal domain
NM_001373186.2 → NP_001359512.1 Girdin homolog [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

COG1196
Location:281 → 1083

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
NM_001269889.3 → NP_001256818.1 Girdin homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256818.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F3Y5P4

Conserved Domains (1) summary

COG1196
Location:115 → 917

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]