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    gcy-22 Receptor-type guanylate cyclase gcy-22 [ Caenorhabditis elegans ]

    Gene ID: 180365, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-22
    Official Full Name
    Receptor-type guanylate cyclase gcy-22
    Primary source
    WormBase:WBGene00001547
    Locus tag
    CELE_T03D8.5
    See related
    AllianceGenome:WB:WBGene00001547
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including response to lithium ion; response to magnesium ion; and response to methionine. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in ASER. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-22 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (20820118..20825062, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Bm594 Neighboring gene ncRNA Neighboring gene ShKT domain-containing protein Neighboring gene Gamma-glutamyltransferase;Gamma-glutamyltranspeptidase 1 Neighboring gene Ground-like domain-containing protein Neighboring gene Neuroendocrine protein 7B2 Neighboring gene Numb-related protein 1;PID domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans che-5 is allelic to gcy-22. Kunitomo H, et al. MicroPubl Biol, 2020 Oct 8. PMID 33313485, Free PMC Article
    2. Neuron-specific regulation of superoxide dismutase amid pathogen-induced gut dysbiosis. Horspool AM, et al. Redox Biol, 2018 Jul. PMID 29857312, Free PMC Article
    3. Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Adachi T, et al. Genetics, 2010 Dec. PMID 20837997, Free PMC Article
    4. A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. Kaplan JM, et al. Proc Natl Acad Sci U S A, 1993 Mar 15. PMID 8460126, Free PMC Article
    5. Defining specificity determinants of cGMP mediated gustatory sensory transduction in Caenorhabditis elegans. Smith HK, et al. Genetics, 2013 Aug. PMID 23695300, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to lithium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to magnesium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to methionine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-22
    NP_001263951.1
    • Confirmed by transcript evidence
    NP_001263952.1
    • Confirmed by transcript evidence
    NP_508018.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20820118..20825062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075617.5 → NP_508018.2  Receptor-type guanylate cyclase gcy-22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508018.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      J7SA55, J7SF90, Q9XTY1
      Conserved Domains (6) summary
      smart00044
      Location:831 → 1023
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:858 → 1044
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:48 → 399
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:791 → 852
      HNOBA; Heme NO binding associated
      cl10011
      Location:28 → 408
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21453
      Location:553 → 795
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001277023.4 → NP_001263952.1  Receptor-type guanylate cyclase gcy-22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263952.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTY1
      Conserved Domains (4) summary
      smart00044
      Location:827 → 1019
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd06352
      Location:27 → 411
      PBP1_NPR_GC-like; ligand-binding domain of membrane guanylyl-cyclase receptors
      pfam07701
      Location:787 → 848
      HNOBA; Heme NO binding associated
      cl21453
      Location:549 → 791
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001277022.3 → NP_001263951.1  Receptor-type guanylate cyclase gcy-22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263951.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XTY1
      Conserved Domains (4) summary
      smart00044
      Location:823 → 1015
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd06352
      Location:27 → 411
      PBP1_NPR_GC-like; ligand-binding domain of membrane guanylyl-cyclase receptors
      pfam07701
      Location:783 → 844
      HNOBA; Heme NO binding associated
      cl21453
      Location:545 → 787
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTY1.2

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