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    CBP6 Cbp6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CBP6
    Official Full Name
    Cbp6p
    Primary source
    SGD:S000000324
    Locus tag
    YBR120C
    See related
    AllianceGenome:SGD:S000000324; FungiDB:YBR120C; VEuPathDB:YBR120C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ribosome binding activity. Involved in mitochondrial respiratory chain complex III assembly and positive regulation of mitochondrial translation. Located in mitochondrial ribosome. Part of Cbp3p-Cbp6 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CBP6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (480435..480923, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene translation elongation factor EF-1 alpha Neighboring gene Mud1p Neighboring gene glycine--tRNA ligase Neighboring gene mitochondrial 54S ribosomal protein YmL36

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of the mitochondrial membrane system. CBP6, a yeast nuclear gene necessary for synthesis of cytochrome b. Dieckmann CL, et al. J Biol Chem, 1985 Feb 10. PMID 2981859
    2. Mutational analysis of yeast mitochondrial translational activator Cbs2p and of YHR063Cp, a protein with similarity to Cbs2p. Tzschoppe K, et al. Curr Genet, 1999 Oct. PMID 10541857
    3. Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly. Ndi M, et al. J Biol Chem, 2019 Nov 8. PMID 31537648, Free PMC Article
    4. Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. Gruschke S, et al. J Cell Biol, 2011 Jun 13. PMID 21670217, Free PMC Article
    5. Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis. Kühl I, et al. Mitochondrion, 2012 May. PMID 22349564, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicate that the essential role of Cbp3 and Cbp6 is to assist Cytb hemylation and demonstrate that in the absence of heme b, Cytb can form non-functional supercomplexes with cytochrome c oxidase.
      Title: Cbp3 and Cbp6 are dispensable for synthesis regulation of cytochrome b in yeast mitochondria.
    2. Cbp3-Cbp6 also coordinates cytochrome b synthesis with bc(1) complex assembly.
      Title: The Cbp3-Cbp6 complex coordinates cytochrome b synthesis with bc(1) complex assembly in yeast mitochondria.
    3. Results suggest that synthesis of cytochrome b occurs preferentially on those ribosomes that have the Cbp3-Cbp6 complex bound to their tunnel exit, an arrangement that may ensure tight coordination of cytochrome b synthesis and assembly.
      Title: Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cbp3p-Cbp6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cbp3p-Cbp6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cbp3p-Cbp6 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrial ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cbp6p
    NP_009678.3
    • Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      480435..480923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178468.3 → NP_009678.3  TPA: Cbp6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009678.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQB8, E9P8V5, P07253
      UniProtKB/TrEMBL
      A6ZL65, B3LN35, B5VE80, C7GY05, G2W9C5, N1P6N6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07253.1

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