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    RHO4 Rho family GTPase RHO4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RHO4
    Official Full Name
    Rho family GTPase RHO4
    Primary source
    SGD:S000001763
    Locus tag
    YKR055W
    See related
    AllianceGenome:SGD:S000001763; FungiDB:YKR055W; VEuPathDB:YKR055W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity. Involved in maintenance of cell polarity and positive regulation of formin-nucleated actin cable assembly. Located in cellular bud neck; incipient cellular bud site; and plasma membrane. Orthologous to several human genes including RND1 (Rho family GTPase 1); RND2 (Rho family GTPase 2); and RND3 (Rho family GTPase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RHO4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (548216..549091)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene sphinganine kinase YSR3 Neighboring gene dynein heavy chain Neighboring gene tRNA (uracil(54)-C(5))-methyltransferase Neighboring gene ribosomal 40S subunit protein S21A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae. Matsui Y, et al. Gene, 1992 May 1. PMID 1587484
    2. The RHO4a and NUD1 genes on Saccharomyces cerevisiae chromosome XI. Van Vliet-Reedijk JC, et al. Yeast, 1993 Oct. PMID 8256523
    3. Genetic analysis of the Saccharomyces cerevisiae RHO3 gene, encoding a rho-type small GTPase, provides evidence for a role in bud formation. Imai J, et al. Genetics, 1996 Feb. PMID 8852836, Free PMC Article
    4. Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. Imamura H, et al. EMBO J, 1997 May 15. PMID 9184220, Free PMC Article
    5. The yeast Rgd1p is a GTPase activating protein of the Rho3 and rho4 proteins. Doignon F, et al. FEBS Lett, 1999 Oct 15. PMID 10526184

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bem2 might be a novel GTPase-activating protein for Rho4 in Saccharomyces cerevisiae.
      Title: Control of polarized growth by the Rho family GTPase Rho4 in budding yeast: requirement of the N-terminal extension of Rho4 and regulation by the Rho GTPase-activating protein Bem2.
    2. Wsc1p participates in the regulation of a Rho3/4-dependent cellular mechanism.
      Title: The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of formin-nucleated actin cable assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of formin-nucleated actin cable assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho family GTPase RHO4
    NP_012981.3
    • Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      548216..549091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179845.3 → NP_012981.3  TPA: Rho family GTPase RHO4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012981.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXB6, P30618, Q00246
      UniProtKB/TrEMBL
      G2WI83, N1NZI1
      Conserved Domains (1) summary
      cd04132
      Location:70 → 248
      Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00246.2

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