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    DIF1 Dif1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851157, updated on 9-Dec-2024

    Summary

    Official Symbol
    DIF1
    Official Full Name
    Dif1p
    Primary source
    SGD:S000004429
    Locus tag
    YLR437C
    See related
    AllianceGenome:SGD:S000004429; FungiDB:YLR437C; VEuPathDB:YLR437C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SDH1
    Summary
    Predicted to enable ribonucleoside-diphosphate reductase inhibitor activity. Involved in protein import into nucleus. Is active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See DIF1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1011622..1012023, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Tsr2p Neighboring gene Ecm30p Neighboring gene ornithine-oxo-acid transaminase Neighboring gene U4/U6-U5 snRNP complex subunit LSM3

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in protein import into nucleus PubMed 
    involved_in protein localization  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    is_active_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    Dif1p
    NP_013541.3
    • Protein that regulates nuclear import of Rnr2p and Rnr4p; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half shows similarity to S. pombe Spd1 protein; DIF1 has a paralog, SML1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1011622..1012023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182325.3 → NP_013541.3  TPA: Dif1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013541.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3RHU5, C8ZE43, D6VZ71, O13577
      UniProtKB/TrEMBL
      G2WJP7, N1P1Y3
      Conserved Domains (1) summary
      pfam08591
      Location:38 → 66
      RNR_inhib; Ribonucleotide reductase inhibitor
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