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    SEC39 Sec39p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC39
    Official Full Name
    Sec39p
    Primary source
    SGD:S000004432
    Locus tag
    YLR440C
    See related
    AllianceGenome:SGD:S000004432; FungiDB:YLR440C; VEuPathDB:YLR440C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DSL3
    Summary
    Involved in ER-dependent peroxisome organization and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum membrane and nuclear envelope. Part of Dsl1/NZR complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC39 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1015568..1017697, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene U4/U6-U5 snRNP complex subunit LSM3 Neighboring gene mitochondrial 54S ribosomal protein YmL4 Neighboring gene ribosomal 40S subunit protein S1A Neighboring gene chromatin-silencing protein SIR3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tombusvirus replication depends on Sec39p endoplasmic reticulum-associated transport protein. Sasvari Z, et al. Virology, 2013 Dec. PMID 24210096
    2. Isolation of Saccharomyces cerevisiae RNase T1 hypersensitive (rns) mutants and genetic analysis of the RNS1/DSL1 gene. Ishikawa T, et al. J Gen Appl Microbiol, 2005 Apr. PMID 15942868
    3. Structure of a membrane tethering complex incorporating multiple SNAREs. DAmico KA, et al. Nat Struct Mol Biol, 2024 Feb. PMID 38196032, Free PMC Article
    4. Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis. Perry RJ, et al. Eukaryot Cell, 2009 Jun. PMID 19346454, Free PMC Article
    5. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Tripathi A, et al. Nat Struct Mol Biol, 2009 Feb. PMID 19151722, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overall, Sec39p is the first peroxisomal biogenesis protein characterized that is critical for tombusvirus replication in yeast and plants.
      Title: Tombusvirus replication depends on Sec39p endoplasmic reticulum-associated transport protein.
    2. SEC20, SEC39, and DSL1 are essential secretory genes involved in the early stages of peroxisome assembly.
      Title: Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.
    3. Dsl3p (Sec39p) is required for the stable interaction of the SNARE Use1p with a central subcomplex consisting of Tip20p and the SNARE proteins Ufe1p and Sec20p. [DSL3]
      Title: Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER-dependent peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Dsl1/NZR complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sec39p
    NP_013545.3
    • Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1015568..1017697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182328.3 → NP_013545.3  TPA: Sec39p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013545.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ75, Q12745, Q7LHI0
      UniProtKB/TrEMBL
      G2WJQ1, N1P097
      Conserved Domains (1) summary
      pfam08314
      Location:7 → 688
      Sec39; Secretory pathway protein Sec39
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12745.1

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