CDC40 Cdc40p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CDC40
Official Full Name: Cdc40p
Primary source: SGD:S000002772
Locus tag: YDR364C
See related: AllianceGenome:SGD:S000002772; FungiDB:YDR364C; VEuPathDB:YDR364C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PRP17; SLT15; SLU4
Summary: Contributes to second spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for second transesterification step; mRNA 3'-splice site recognition; and mRNA branch site recognition. Located in nuclear periphery. Part of spliceosomal complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 15. Orthologous to human CDC40 (cell division cycle 40). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Data show that Prp17 interacts with U2, U5 and U6 snRNPs (small nuclear ribonucleoproteins) but it is not a core component of any one snRNP.
Title: The splicing factor Prp17 interacts with the U2, U5 and U6 snRNPs and associates with the spliceosome pre- and post-catalysis.
Mutants are hydroxyurea- and methylmethane sulfonate-sensitive due to their S-phase entry defect.
Title: A role for the yeast cell cycle/splicing factor Cdc40 in the G1/S transition.
role in splicing of subsets of introns
Title: Genome-wide analysis of pre-mRNA splicing: intron features govern the requirement for the second-step factor, Prp17 in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to second spliceosomal transesterification activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in generation of catalytic spliceosome for second transesterification step	IGI Inferred from Genetic Interaction more info	PubMed
involved_in generation of catalytic spliceosome for second transesterification step	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA 3'-splice site recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA branch site recognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

NP_010652.3

Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition; required for DNA synthesis during mitosis and meiosis; has WD repeats; thermosensitivity of the cdc40 null mutant is functionally complemented by a chimeric construct containing the N-terminal 156 amino acids of yeast Cdc40p fused to the C-terminal two thirds (297 amino acids) of human CDC40

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