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    l(1)10Bb lethal (1) 10Bb [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32069, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(1)10Bbprovided by FlyBase
    Official Full Name
    lethal (1) 10Bbprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001491
    Locus tag
    Dmel_CG1639
    See related
    AllianceGenome:FB:FBgn0001491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10Ba; CG1639; Dmel\CG1639; L(1)10Bb; l(1)G0169; l(1)G14; l(1)GLM14
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human BUD31 (BUD31 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(1)10Bb in Genome Data Viewer
    Location:
    10B3-10B3; 1-34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11324294..11325308, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11218327..11219341, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 10a Neighboring gene sisterless A Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene Kinesin associated protein 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. L(1)10Bb serves as a conservative determinant for soma-germline communications via cellular non-autonomous effects within the testicular stem cell niche. He L, et al. Mol Cell Endocrinol, 2024 Sep 15. PMID 38795826
    2. A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex. Erickson JW, et al. Genes Dev, 1993 Sep. PMID 8370520
    3. The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Hanratty WP, et al. Mol Gen Genet, 1993 Apr. PMID 8479437
    4. Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails. Sarpal R, et al. Curr Biol, 2003 Sep 30. PMID 14521834
    5. Key aspects of the primary sex determination mechanism are conserved across the genus Drosophila. Erickson JW, et al. Development, 1998 Aug. PMID 9671597

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (1) 10Bb
    Names
    CG1639-PA
    l(1)10Bb-PA
    lethal(1)10Bb

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11324294..11325308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078562.3 → NP_511117.1  lethal (1) 10Bb [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97454
      Related
      FBpp0073316
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97454 O97454

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