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    Spmip8 sperm microtubule inner protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 73407, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spmip8provided by MGI
    Official Full Name
    sperm microtubule inner protein 8provided by MGI
    Primary source
    MGI:MGI:1920657
    See related
    Ensembl:ENSMUSG00000090206 AllianceGenome:MGI:1920657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tepp; 1700055M20Rik
    Summary
    Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human SPMIP8 (sperm microtubule inner protein 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 72.3) and whole brain E14.5 (RPKM 2.2) See more
    Orthologs
    human all
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    Genomic context

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    See Spmip8 in Genome Data Viewer
    Location:
    8 C5; 8 47.12 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96038148..96053239)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95311569..95326211)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97769227-97769421 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97771323-97771506 Neighboring gene cyclic nucleotide gated channel beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E3796 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 6 Neighboring gene STARR-positive B cell enhancer ABC_E8259 Neighboring gene zinc finger protein 319 Neighboring gene U6 snRNA biogenesis 1 Neighboring gene matrix metallopeptidase 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Bera TK, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14652002
    2. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
    3. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107117

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sperm microtubule inner protein 8
    Names
    testis, prostate and placenta expressed
    testis, prostate and placenta-expressed protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028532.3 → NP_082808.1  sperm microtubule inner protein 8 isoform 2

      See identical proteins and their annotated locations for NP_082808.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC102518, AK006802, BY706785
      Consensus CDS
      CCDS22558.1
      UniProtKB/Swiss-Prot
      Q6IMH0
      Related
      ENSMUSP00000096080.3, ENSMUST00000098480.9

    2. NM_199455.2 → NP_955534.1  sperm microtubule inner protein 8 isoform 1

      See identical proteins and their annotated locations for NP_955534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102518, BC087870, BY706785
      Consensus CDS
      CCDS22557.1
      UniProtKB/Swiss-Prot
      Q3SXB6, Q6IMH0, Q9D9K7
      UniProtKB/TrEMBL
      D3YY82
      Related
      ENSMUSP00000125362.2, ENSMUST00000161029.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96038148..96053239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154321.1 → XP_036010214.1  sperm microtubule inner protein 8 isoform X3

      UniProtKB/Swiss-Prot
      Q3SXB6, Q6IMH0, Q9D9K7
      UniProtKB/TrEMBL
      D3YY82

    2. XM_036154322.1 → XP_036010215.1  sperm microtubule inner protein 8 isoform X3

      UniProtKB/Swiss-Prot
      Q3SXB6, Q6IMH0, Q9D9K7
      UniProtKB/TrEMBL
      D3YY82

    3. XM_036154323.1 → XP_036010216.1  sperm microtubule inner protein 8 isoform X4

    4. XM_036154317.1 → XP_036010210.1  sperm microtubule inner protein 8 isoform X1

    5. XM_036154316.1 → XP_036010209.1  sperm microtubule inner protein 8 isoform X1

    6. XM_036154319.1 → XP_036010212.1  sperm microtubule inner protein 8 isoform X1

    7. XM_036154318.1 → XP_036010211.1  sperm microtubule inner protein 8 isoform X1

    8. XM_036154320.1 → XP_036010213.1  sperm microtubule inner protein 8 isoform X2

    9. XM_006531402.3 → XP_006531465.1  sperm microtubule inner protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006531465.1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IMH0.1 GenPept UniProtKB/Swiss-Prot:Q6IMH0

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