Cpne5 copine V [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpne5provided by MGI
Official Full Name: copine Vprovided by MGI
Primary source: MGI:MGI:2385908
See related: Ensembl:ENSMUSG00000024008 AllianceGenome:MGI:2385908
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A830083G22Rik
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
Expression: Broad expression in frontal lobe adult (RPKM 12.0), genital fat pad adult (RPKM 10.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.14 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (29375495..29456764, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (29156521..29237790, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study generated Cpne5 KO mice model and found that Cpne5 deficiency did not affect rodent locomotor activity and memory, but significantly decrease rodent anxiety level in elevated plus maze and elevated platform tasks, which indicates the important role of Cpne5 in regulating anxiety level.
Title: Cpne5 is Involved in Regulating Rodent Anxiety Level.
Our results demonstrate that CPNE5 is expressed in both neural progenitor cells and the differentiated neurons during the neural development, which suggests that CPNE5 might play an important role in the development of murine central nervous system.
Title: Localization and cellular distribution of CPNE5 in embryonic mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-50g7 (e-PCR)
- UniSTS:257891

Cpne5 (e-PCR), detects polymorphism
- UniSTS:547201

338D4-T7 (e-PCR), detects polymorphism
- UniSTS:140935

58C20-SP6 (e-PCR), detects polymorphism
- UniSTS:140978

D17Mit145 (e-PCR), detects polymorphism
- UniSTS:127972

BE110298 (e-PCR)
- UniSTS:245230

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendrite extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: copine-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360239.1 → NP_001347168.1 copine-5 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC162182, AC167363

Conserved Domains (3) summary

cd04047
Location:194 → 305

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:23 → 137

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:315 → 571

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
NM_153166.2 → NP_694806.1 copine-5 isoform 2

See identical proteins and their annotated locations for NP_694806.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter, compared to isoform 1.

Source sequence(s)

AC162182, AC167363, AK044042

Consensus CDS

CCDS28592.1

UniProtKB/Swiss-Prot

Q8JZW4

Related

ENSMUSP00000024805.8, ENSMUST00000024805.15

Conserved Domains (3) summary

cd04047
Location:177 → 288

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:23 → 137

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:298 → 554

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

29375495..29456764 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160602.1 → XP_036016495.1 copine-5 isoform X1

Conserved Domains (2) summary

cd04047
Location:29 → 140

C2B_Copine; C2 domain second repeat in Copine

cd01459
Location:150 → 406

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
XM_006524251.1 → XP_006524314.1 copine-5 isoform X2

Conserved Domains (2) summary

cd04047
Location:46 → 157

C2B_Copine; C2 domain second repeat in Copine

cd01459
Location:167 → 423

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
XM_017317469.3 → XP_017172958.1 copine-5 isoform X3

Conserved Domains (1) summary

cd01459
Location:2 → 262

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
XM_017317468.3 → XP_017172957.1 copine-5 isoform X4

Related

ENSMUST00000126993.8

Conserved Domains (1) summary

pfam07002
Location:1 → 213

Copine