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    Car2 carbonic anhydrase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54231, updated on 9-Dec-2024

    Summary

    Official Symbol
    Car2provided by RGD
    Official Full Name
    carbonic anhydrase 2provided by RGD
    Primary source
    RGD:2240
    See related
    EnsemblRapid:ENSRNOG00000009629 AllianceGenome:RGD:2240
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca2
    Summary
    Enables carbonate dehydratase activity. Involved in several processes, including estrous cycle; positive regulation of bone resorption; and positive regulation of osteoclast differentiation. Located in several cellular components, including apical part of cell; basolateral plasma membrane; and microvillus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (carbonic anhydrase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 2474.6), Kidney (RPKM 1633.5) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Car2 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (88462883..88478012, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (86741625..86756766, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (88097740..88112868, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit sigma 1, pseudogene 2 Neighboring gene eukaryotic translation initiation factor 5A-pseudogene 2 Neighboring gene carbonic anhydrase 3 Neighboring gene carbonic anhydrase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arylesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbonate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyanamide hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiotensin-activated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in carbon dioxide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within carbon dioxide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fluid shear stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in estrous cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in kidney development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in osteoclast differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cellular pH reduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dipeptide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dipeptide transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bone resorption TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cellular pH TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of chloride transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intracellular pH ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of monoatomic anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of monoatomic anion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to formaldehyde IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to pH IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within secretion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    carbonic anhydrase 2
    Names
    CA-II
    carbonate dehydratase II
    carbonic anhydrase II
    cyanamide hydratase CA2
    NP_062164.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019291.1NP_062164.1  carbonic anhydrase 2

      See identical proteins and their annotated locations for NP_062164.1

      Status: PROVISIONAL

      Source sequence(s)
      X58294
      UniProtKB/Swiss-Prot
      P27139
      UniProtKB/TrEMBL
      A0A8I6AMP9, A6IH09
      Related
      ENSRNOP00000013354.3, ENSRNOT00000013354.8
      Conserved Domains (1) summary
      cl00012
      Location:1259
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      88462883..88478012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)