tutl turtle [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tutlprovided by FlyBase
Official Full Name: turtleprovided by FlyBase
Primary source: FLYBASE:FBgn0010473
Locus tag: Dmel_CG15427
See related: AllianceGenome:FB:FBgn0010473
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15426; CG15427; CG15428; CT35489; CT35490; Dmel\CG15427; jf4; l(2)01085; l(2)24Df; l(2)jf4; mdcds_7441; Tutl
Summary: Enables cell-cell adhesion mediator activity. Involved in several processes, including flight behavior; mechanosensory behavior; and neuron development. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including central nervous system; epithelium; ganglia; larval multidendritic neurons; and synaptic neuropil domain. Orthologous to several human genes including IGSF9B (immunoglobulin superfamily member 9B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 24E1-24E1; 2-12 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4283148..4323781)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4283148..4323781)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tutl interacts with Bdl in mediating axon-glia recognition for WG extension and axon ensheathment.
Title: Turtle interacts with borderless in regulating glial extension and axon ensheathment.
Tutl interacts with Borderless (Bdl) in controlling R7 axonal tiling phenotype and may downregulate R7 axon-axon adhesion by interacting with Bdl.
Title: Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless.
Turtle is downstream effector of Cut-mediated regulation of da neuron dendrite morphology.
Title: Turtle functions downstream of Cut in differentially regulating class specific dendrite morphogenesis in Drosophila.
Tutl controls R7 tiling by preventing fusion between adjacent R7 axons; it mediates homophilic cell-cell interactions; suggests Tutl-mediated terminal-terminal recognition functions in parallel to intrinsic growth control mediated by Activin pathway
Title: The conserved Ig superfamily member Turtle mediates axonal tiling in Drosophila.
This study indicated that the turtle proteins function as axon guidance cues that promote midline attraction, axon branching, and axonal invasiveness.
Title: The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding.
tutl gene is required to restrain dendrite branch formation in neurons with simple arbors, and to promote dendrite self-avoidance in neurons with complex arbors.
Title: Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cell-cell adhesion mediator activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R7 cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal defasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flight behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in larval behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: turtle

Names: CG15427-PA; CG15427-PC; CG15427-PD; CG15427-PE; CG15427-PF; CG15427-PG; CG15427-PH; CG15427-PI; CG15427-PJ; CG15427-PK; lethal(2)24Df; tutl-PA; tutl-PC; tutl-PD; tutl-PE; tutl-PF; tutl-PG; tutl-PH; tutl-PI; tutl-PJ; tutl-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

4283148..4323781

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273091.1 → NP_001260020.1 turtle, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260020.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHT0

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:549 → 628

IG_like; Immunoglobulin like

cd00063
Location:633 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:349 → 437

Ig; Immunoglobulin domain
NM_001273090.1 → NP_001260019.1 turtle, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260019.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NR34, Q8IQ17, Q967D7, Q967D8, Q967D9, Q967E0, Q9VQY0, Q9VQY1, Q9VQY2

UniProtKB/TrEMBL

M9PCI8

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:574 → 653

IG_like; Immunoglobulin like

cd00063
Location:658 → 750

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:374 → 462

Ig; Immunoglobulin domain
NM_001316379.1 → NP_001303308.1 turtle, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WIF3

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:549 → 628

IG_like; Immunoglobulin like

cd00063
Location:633 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:349 → 437

Ig; Immunoglobulin domain
NM_001316378.1 → NP_001303307.1 turtle, isoform J [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NR34, Q8IQ17, Q967D7, Q967D8, Q967D9, Q967E0, Q9VQY0, Q9VQY1, Q9VQY2

UniProtKB/TrEMBL

A0A0S0WJJ4

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:549 → 628

IG_like; Immunoglobulin like

cd00063
Location:633 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:349 → 437

Ig; Immunoglobulin domain
NM_001169397.2 → NP_001162868.1 turtle, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162868.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHT0

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:549 → 628

IG_like; Immunoglobulin like

cd00063
Location:633 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:349 → 437

Ig; Immunoglobulin domain
NM_164576.4 → NP_722967.2 turtle, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722967.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NR34, Q8IQ17, Q967D7, Q967D8, Q967D9, Q967E0, Q9VQY0, Q9VQY1, Q9VQY2

UniProtKB/TrEMBL

E1JHS9

Related

FBpp0088327

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:549 → 628

IG_like; Immunoglobulin like

cd00063
Location:633 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:349 → 437

Ig; Immunoglobulin domain
NM_080127.6 → NP_524866.4 turtle, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524866.4

Status: REVIEWED

UniProtKB/TrEMBL

C0PTW0

Related

FBpp0088328

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:549 → 628

IG_like; Immunoglobulin like

cd00063
Location:633 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:349 → 437

Ig; Immunoglobulin domain
NM_164577.3 → NP_722968.1 turtle, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722968.1

Status: REVIEWED

UniProtKB/TrEMBL

C0PTW0

Related

FBpp0088326

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:549 → 628

IG_like; Immunoglobulin like

cd00063
Location:633 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:349 → 437

Ig; Immunoglobulin domain
NM_164578.4 → NP_722969.1 turtle, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722969.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q967D7

Related

FBpp0088325

Conserved Domains (4) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:137 → 229

IG_like; Immunoglobulin like

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain
NM_001169398.1 → NP_001162869.1 turtle, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162869.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NR34, Q8IQ17, Q967D7, Q967D8, Q967D9, Q967E0, Q9VQY0, Q9VQY1, Q9VQY2

UniProtKB/TrEMBL

E1JHS9

Conserved Domains (6) summary

smart00408
Location:268 → 331

IGc2; Immunoglobulin C-2 Type

smart00410
Location:549 → 628

IG_like; Immunoglobulin like

cd00063
Location:633 → 725

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:253 → 341

I-set; Immunoglobulin I-set domain

pfam07686
Location:137 → 250

V-set; Immunoglobulin V-set domain

cl11960
Location:349 → 437

Ig; Immunoglobulin domain