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    drl derailed [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44355, updated on 9-Dec-2024

    Summary

    Official Symbol
    drlprovided by FlyBase
    Official Full Name
    derailedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015380
    Locus tag
    Dmel_CG17348
    See related
    AllianceGenome:FB:FBgn0015380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10758; CG17348; Dmel\CG17348; Drl; DRL; lin; lio; lio/drl
    Summary
    Enables several functions, including Wnt receptor activity; Wnt-protein binding activity; and protein dimerization activity. Involved in several processes, including determination of muscle attachment site; learning or memory; and neuron projection guidance. Located in axon; dendrite; and plasma membrane. Part of receptor complex. Is expressed in several structures, including A1-7 lateral transverse muscle cell; anlage in statu nascendi; brain; head epidermis primordium; and synaptic neuropil subdomain. Used to study intellectual disability. Orthologous to human RYK (receptor like tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See drl in Genome Data Viewer
    Location:
    37C7-37C7; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19190342..19208621)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19190342..19208621)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene gamma-Tubulin at 37C Neighboring gene pigeon Neighboring gene long non-coding RNA:CR46209 Neighboring gene long non-coding RNA:CR44189

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Wnt receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Wnt receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemorepulsion of axon IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chemorepulsion of axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendrite guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of muscle attachment site IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in haltere development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mushroom body development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in olfactory learning TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    derailed
    Names
    CG17348-PA
    CG17348-PB
    drl-PA
    drl-PB
    linotte
    lionette

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19190342..19208621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057791.4NP_477139.1  derailed, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27324, Q9U9Y3, Q9VIY6
      Related
      FBpp0080736
      Conserved Domains (3) summary
      smart00469
      Location:21157
      WIF; Wnt-inhibitory factor-1 like domain
      cd05043
      Location:336606
      PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
      pfam07714
      Location:343599
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001273637.1NP_001260566.1  derailed, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDD9
      Conserved Domains (3) summary
      smart00469
      Location:21157
      WIF; Wnt-inhibitory factor-1 like domain
      cd05043
      Location:336606
      PTK_Ryk; Pseudokinase domain of Ryk (Receptor related to tyrosine kinase)
      pfam07714
      Location:343599
      Pkinase_Tyr; Protein tyrosine kinase