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    CG42694 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 10178792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42694provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261584
    Locus tag
    Dmel_CG42694
    See related
    AllianceGenome:FB:FBgn0261584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG42694; SPH247
    Summary
    Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42694 in Genome Data Viewer
    Location:
    59B7-59B7; 2-101 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22941877..22945147)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18829400..18832670)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene CCHC-type zinc finger nucleic acid binding protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like Holozoa Neighboring gene mir-9376 stem loop Neighboring gene long non-coding RNA:CR32835

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The tobacco phosphatidylethanolamine-binding protein NtFT4 increases the lifespan of Drosophila melanogaster by interacting with the proteostasis network. Känel P, et al. Aging (Albany NY), 2022 Apr 8. PMID 35396341, Free PMC Article
    2. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article
    3. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article
    4. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Sanfilippo P, et al. Genome Biol, 2017 Nov 30. PMID 29191225, Free PMC Article
    5. Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster. Liu X, et al. RNA, 2017 Dec. PMID 28851752, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42694-PA
    CG42694-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22941877..22945147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274218.2 → NP_001261147.1  uncharacterized protein Dmel_CG42694, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261147.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD89
      Conserved Domains (2) summary
      smart00020
      Location:46 → 253
      Tryp_SPc; Trypsin-like serine protease
      cl21584
      Location:46 → 256
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001202065.2 → NP_001188994.1  uncharacterized protein Dmel_CG42694, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188994.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD89
      Conserved Domains (2) summary
      smart00020
      Location:46 → 253
      Tryp_SPc; Trypsin-like serine protease
      cl21584
      Location:46 → 256
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD89 A0A0B4JD89

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