U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    bab2 bric a brac 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44254, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    bab2provided by FlyBase
    Official Full Name
    bric a brac 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0025525
    Locus tag
    Dmel_CG9102
    See related
    AllianceGenome:FB:FBgn0025525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bab; BAB; bab-II; Bab2; BAB2; BTB-II; BtbII; CG13911; CG9102; Dmel\CG9102
    Summary
    Enables minor groove of adenine-thymine-rich DNA binding activity. Involved in female gonad morphogenesis; imaginal disc morphogenesis; and regulation of stem cell differentiation. Located in nucleus and polytene chromosome. Is expressed in several structures, including central nervous system; gut section; imaginal disc; tarsal segment; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See bab2 in Genome Data Viewer
    Location:
    61F2-61F3; 3-0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1140429..1177276, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1140429..1177276, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene trio Neighboring gene uncharacterized protein Neighboring gene bric a brac 1 Neighboring gene uncharacterized protein Neighboring gene Tryptophan hydroxylase neuronal Neighboring gene Lysozyme X

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic mechanisms and constraints governing the evolution of correlated traits in drosophilid flies. Gompel N, et al. Nature, 2003 Aug 21. PMID 12931186
    2. Pattern formation in the limbs of Drosophila: bric à brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus. Godt D, et al. Development, 1993 Nov. PMID 7910551
    3. Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogaster. Kopp A, et al. Genetics, 2003 Feb. PMID 12618413, Free PMC Article
    4. The evolution of Bab paralog expression and abdominal pigmentation among Sophophora fruit fly species. Salomone JR, et al. Evol Dev, 2013 Nov-Dec. PMID 24261445
    5. Mechanisms of cell rearrangement and cell recruitment in Drosophila ovary morphogenesis and the requirement of bric à brac. Godt D, et al. Development, 1995 Jan. PMID 7867498

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development.
      Title: Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development.
    2. The Bric-a-Brac BTB/POZ transcription factors are necessary in niche cells for germline stem cells establishment and homeostasis through control of BMP/DPP signaling in the Drosophila melanogaster ovary.
      Title: The Bric-à-Brac BTB/POZ transcription factors are necessary in niche cells for germline stem cells establishment and homeostasis through control of BMP/DPP signaling in the Drosophila melanogaster ovary.
    3. Genetic variation at the bab locus affects bab expression and female abdominal pigmentation. Expression levels vary with temperature, participate in the pigmentation difference between the Dark and Pale lines.
      Title: bric à brac (bab), a central player in the gene regulatory network that mediates thermal plasticity of pigmentation in Drosophila melanogaster.
    4. In Drosophila melanogaster, dimorphic pigmentation is controlled by the dimorphic expression of the paralogous Bab1 and Bab2 transcription factors that repress pigmentation.
      Title: The evolution of Bab paralog expression and abdominal pigmentation among Sophophora fruit fly species.
    5. targeted loss of function of bric-a-brac 2 (bab2) affects morphogenesis without changing somatic gonad precursors cell number
      Title: Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila.
    6. Sequence variation at the bric a brac (bab) locus of Drosophila melanogaster, was examined.
      Title: Contrasting patterns of sequence evolution at the functionally redundant bric à brac paralogs in Drosophila melanogaster.
    7. The tissue distribution of Bab1 and Bab2 overlaps, with Bab1 being expressed in a subpattern of Bab2.
      Title: The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables minor groove of adenine-thymine-rich DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in eye-antennal disc morphogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in female gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leg disc morphogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    bric a brac 2
    Names
    BTB-protein-II
    Bric-a-brac 2
    CG9102-PA
    CG9102-PB
    bab2-PA
    bab2-PB
    bric a brac
    bric a brac II
    bric-a-brac
    bric-a-brac-2
    bric-a-brac2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1140429..1177276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274313.1 → NP_001261242.1  bric a brac 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBH6
      Conserved Domains (3) summary
      smart00225
      Location:224 → 309
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:213 → 309
      BTB; BTB/POZ domain
      pfam05225
      Location:644 → 689
      HTH_psq; helix-turn-helix, Psq domain

    2. NM_079155.3 → NP_523879.2  bric a brac 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523879.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24001, Q7YU69, Q9U1H3, Q9W0K4
      Related
      FBpp0072535
      Conserved Domains (3) summary
      smart00225
      Location:224 → 309
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:213 → 309
      BTB; BTB/POZ domain
      pfam05225
      Location:645 → 690
      HTH_psq; helix-turn-helix, Psq domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBH6 M9PBH6
    Q9W0K4.2 Q9W0K4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools