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    tty tweety [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33109, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttyprovided by FlyBase
    Official Full Name
    tweetyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015558
    Locus tag
    Dmel_CG1693
    See related
    AllianceGenome:FB:FBgn0015558
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1693; Dmel\CG1693; TTYH1; twe
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity and volume-sensitive chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including TTYH1 (tweety family member 1) and TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tty in Genome Data Viewer
    Location:
    19F4-19F5; 1-65 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21328613..21339676, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21199640..21210703, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Dullard Neighboring gene uncharacterized protein Neighboring gene flightless I Neighboring gene dodo Neighboring gene penguin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila tweety facilitates autophagy to regulate mitochondrial homeostasis and bioenergetics in Glia. Leung HH, et al. Glia, 2024 Feb. PMID 37870193,
    2. The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. Campbell HD, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248259, Free PMC Article
    3. The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels. Suzuki M. Exp Physiol, 2006 Jan. PMID 16219661
    4. Population genetics: the signature of selection. Brookfield JF. Curr Biol, 2001 May 15. PMID 11378402
    5. Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Hsu T, et al. Nat Cell Biol, 2001 Jun. PMID 11389437

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila tweety facilitates autophagy to regulate mitochondrial homeostasis and bioenergetics in Glia.
      Title: Drosophila tweety facilitates autophagy to regulate mitochondrial homeostasis and bioenergetics in Glia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    mobile_element

    • Loc: c21332551-21332478 mobile_element_type = transposon:INE-1{}6147

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables intracellularly calcium-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables volume-sensitive chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tweety
    Names
    CG1693-PA
    CG1693-PC
    CG1693-PD
    CG1693-PE
    CG1693-PF
    CG1693-PG
    tty-PA
    tty-PC
    tty-PD
    tty-PE
    tty-PF
    tty-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21328613..21339676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272840.2 → NP_001259769.1  tweety, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFD6
      Conserved Domains (1) summary
      cd07912
      Location:10 → 429
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    2. NM_167744.4 → NP_728415.4  tweety, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728415.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61343, Q8IQ48, Q9U6L4, Q9VRG9
      Conserved Domains (1) summary
      cd07912
      Location:10 → 429
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    3. NM_001272839.2 → NP_001259768.1  tweety, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFD6
      Conserved Domains (1) summary
      cd07912
      Location:10 → 429
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    4. NM_001272837.2 → NP_001259766.1  tweety, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259766.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI39
      Conserved Domains (1) summary
      cd07912
      Location:10 → 429
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    5. NM_080712.7 → NP_542443.4  tweety, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_542443.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61343, Q8IQ48, Q9U6L4, Q9VRG9
      Related
      FBpp0076919
      Conserved Domains (1) summary
      cd07912
      Location:10 → 429
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

    6. NM_001272838.1 → NP_001259767.1  tweety, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI22
      Conserved Domains (1) summary
      cd07912
      Location:10 → 429
      Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFD6 M9PFD6
    M9PI22 M9PI22
    M9PI39 M9PI39
    Q9U6L4.1 Q9U6L4

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