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    MICU3 Mitochondrial calcium uptake 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MICU3provided by FlyBase
    Official Full Name
    Mitochondrial calcium uptake 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0038735
    Locus tag
    Dmel_CG4662
    See related
    AllianceGenome:FB:FBgn0038735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4662; Dmel\CG4662; micu3
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be part of uniplex complex. Is expressed in adult head. Orthologous to several human genes including MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MICU3 in Genome Data Viewer
    Location:
    92B3-92B3; 3-67 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19847311..19854403)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15673033..15680125)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-AGT 1-7 Neighboring gene branchless Neighboring gene uncharacterized protein Neighboring gene Inositol-requiring enzyme-1 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial rRNA methyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene Multidrug resistance protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo. Tufi R, et al. Cell Rep, 2019 Apr 30. PMID 31042479, Free PMC Article
    2. Functionally Validating Evolutionary Conserved Risk Genes for Parkinson's Disease in Drosophila melanogaster. Baisgaard AE, et al. Insects, 2023 Feb 9. PMID 36835737, Free PMC Article
    3. Sex-specific splicing in Drosophila: widespread occurrence, tissue specificity and evolutionary conservation. Telonis-Scott M, et al. Genetics, 2009 Feb. PMID 19015538, Free PMC Article
    4. Milton assembles large mitochondrial clusters, mitoballs, to sustain spermatogenesis. Li AYZ, et al. Proc Natl Acad Sci U S A, 2023 Aug 22. PMID 37579146, Free PMC Article
    5. Sex-specific expression of alternative transcripts in Drosophila. McIntyre LM, et al. Genome Biol, 2006. PMID 16934145, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MICU3 mutants are viable with mild neurological impairment.
      Title: Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of uniplex complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial calcium uptake 3
    Names
    CG4662-PA
    CG4662-PB
    CG4662-PC
    CG4662-PD
    CG4662-PE
    CG4662-PF
    MICU3-PA
    MICU3-PB
    MICU3-PC
    MICU3-PD
    MICU3-PE
    MICU3-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19847311..19854403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169877.2 → NP_732455.1  mitochondrial calcium uptake 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732455.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PE4, Q8IN65
      Related
      FBpp0083224
      Conserved Domains (3) summary
      pfam13499
      Location:394 → 443
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:397 → 446
      EF-hand_8; EF-hand domain pair
      cl08302
      Location:192 → 256
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_001275814.1 → NP_001262743.1  mitochondrial calcium uptake 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262743.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGC9, Q86PE4
      Conserved Domains (2) summary
      pfam13499
      Location:420 → 469
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:423 → 472
      EF-hand_8; EF-hand domain pair

    3. NM_001170186.2 → NP_001163657.1  mitochondrial calcium uptake 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163657.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIQ4, Q86PE4
      Conserved Domains (3) summary
      PTZ00183
      Location:193 → 305
      PTZ00183; centrin; Provisional
      pfam13499
      Location:391 → 440
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:394 → 443
      EF-hand_8; EF-hand domain pair

    4. NM_001275812.1 → NP_001262741.1  mitochondrial calcium uptake 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262741.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHF1, Q86PE4
      Conserved Domains (2) summary
      pfam13499
      Location:421 → 470
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:424 → 473
      EF-hand_8; EF-hand domain pair

    5. NM_001275813.1 → NP_001262742.1  mitochondrial calcium uptake 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGH7, Q86PE4
      Conserved Domains (3) summary
      PTZ00183
      Location:193 → 305
      PTZ00183; centrin; Provisional
      pfam13499
      Location:391 → 440
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:394 → 443
      EF-hand_8; EF-hand domain pair

    6. NM_142576.4 → NP_650833.1  mitochondrial calcium uptake 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PE4, Q95TU0, Q9VDT8
      Related
      FBpp0083223
      Conserved Domains (3) summary
      pfam13499
      Location:394 → 443
      EF-hand_7; EF-hand domain pair
      pfam13833
      Location:397 → 446
      EF-hand_8; EF-hand domain pair
      cl08302
      Location:192 → 256
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGC9 A0A0B4KGC9
    A0A0B4KGH7 A0A0B4KGH7
    A0A0B4KHF1 A0A0B4KHF1
    E1JIQ4 E1JIQ4
    Q86PE4 Q86PE4
    Q8IN65 Q8IN65
    Q9VDT8 Q9VDT8

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