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    trv trivet [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trvprovided by FlyBase
    Official Full Name
    trivetprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085391
    Locus tag
    Dmel_CG34362
    See related
    AllianceGenome:FB:FBgn0085391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE10833; CG12870; CG12872; CG34362; Dmel\CG34362; Tia1-like
    Old locus tag
    CG12870; CG12872; Dmel_CG12870; Dmel_CG12872
    Summary
    Predicted to enable RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See trv in Genome Data Viewer
    Location:
    98B7-98C1; 3-94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28026615..28090740)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23852337..23916462)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46087 Neighboring gene long noncoding RNA: testis-specific 27 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46077 Neighboring gene long non-coding RNA:CR46076

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of alternative splicing by signal-dependent degradation of splicing-regulatory proteins. Katzenberger RJ, et al. J Biol Chem, 2009 Apr 17. PMID 19218244, Free PMC Article
    2. Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. Luo SD, et al. Development, 2011 Jul. PMID 21652649, Free PMC Article
    3. Genetics of alcohol consumption in Drosophila melanogaster. Fochler S, et al. Genes Brain Behav, 2017 Sep. PMID 28627812, Free PMC Article
    4. Genomic Analysis of Genotype-by-Social Environment Interaction for Drosophila melanogaster Aggressive Behavior. Rohde PD, et al. Genetics, 2017 Aug. PMID 28550016, Free PMC Article
    5. Genome wide identification of fruitless targets suggests a role in upregulating genes important for neural circuit formation. Vernes SC. Sci Rep, 2014 Mar 19. PMID 24642956, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trivet
    Names
    CG34362-PA
    CG34362-PE
    CG34362-PF
    CG34362-PI
    CG34362-PJ
    trv-PA
    trv-PE
    trv-PF
    trv-PI
    trv-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28026615..28090740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170283.3 → NP_001163754.3  trivet, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163754.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIZ9, Q1ECA2
      Conserved Domains (2) summary
      cd12353
      Location:313 → 387
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:416 → 491
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

    2. NM_001276104.1 → NP_001263033.1  trivet, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH70
      Conserved Domains (2) summary
      cd12353
      Location:167 → 241
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:270 → 345
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

    3. NM_001276103.1 → NP_001263032.1  trivet, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263032.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHB5
      Conserved Domains (2) summary
      cd12353
      Location:167 → 241
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:270 → 345
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

    4. NM_143352.4 → NP_651609.1  trivet, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAX3
      Related
      FBpp0111495
      Conserved Domains (2) summary
      cd12353
      Location:167 → 241
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:270 → 345
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

    5. NM_001300644.1 → NP_001287573.1  trivet, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIU0
      Conserved Domains (2) summary
      cd12353
      Location:167 → 241
      RRM2_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins p40-TIA-1 and TIAR
      cd12354
      Location:270 → 345
      RRM3_TIA1_like; RNA recognition motif 2 in granule-associated RNA binding proteins (p40-TIA-1 and TIAR), and yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH70 A0A0B4KH70
    A0A0B4KHB5 A0A0B4KHB5
    A0A0B4LIU0 A0A0B4LIU0
    E1JIZ9 E1JIZ9
    Q9VAX3 Q9VAX3

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