Ir25a Ionotropic receptor 25a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ir25aprovided by FlyBase
Official Full Name: Ionotropic receptor 25aprovided by FlyBase
Primary source: FLYBASE:FBgn0031634
Locus tag: Dmel_CG15627
See related: AllianceGenome:FB:FBgn0031634
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 25a; CG15627; CT35778; DmelIR25a; Dmel\CG15627; ir25a; IR25a
Summary: Enables coreceptor activity. Contributes to olfactory receptor activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of smell; entrainment of circadian clock; and temperature compensation of the circadian clock. Located in cilium and sensory dendrite. Is expressed in several structures, including ganglia; organism subdivision; sense organ; sensory nervous system primordium; and sensory neurons. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1) and GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25A8-25A8; 2-13 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4830846..4835300, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4830846..4835300, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster.
Title: Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster.
Ionotropic Receptor-dependent cool cells control the transition of temperature preference in Drosophila larvae.
Title: Ionotropic Receptor-dependent cool cells control the transition of temperature preference in Drosophila larvae.
determination that the evolutionarily conserved ionotropic co-receptor IR25a is required for CO2 attraction, and that the receptors necessary for CO2 avoidance are not involved in this attraction; this study lays the foundation for future research to determine the neural circuits that underlie both state- and odorant-dependent decision-making in Drosophila
Title: Distinct activity-gated pathways mediate attraction and aversion to CO(2) in Drosophila.
Mutation in IR25a gene is associated with loss of appetitive behavioral responses to fatty acids.
Title: Molecular basis of fatty acid taste in Drosophila.
IR25a and IR76b are essential in sour gustatory receptor neurons of females for oviposition preference on acid-containing food.
Title: Ionotropic Receptors Mediate Drosophila Oviposition Preference through Sour Gustatory Receptor Neurons.
Here, the authors discover Drosophila moist cells and show that they require IR25a and IR93a together with IR68a, a conserved, but orphan ionotropic receptor for hygrosensation.
Title: Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila.
The ionotropic receptors IR40a, IR93a, and IR25a are all required for humidity preference in D. melanogaster. Whereas IR40a is selectively required for hygrosensory responses, IR93a and IR25a mediate both humidity and temperature preference. Consistent with this, the expression of IR93a and IR25a includes thermosensory neurons of the arista.
Title: Humidity Sensing in Drosophila.
The authors find that two Ionotropic Receptors, IR21a and IR25a, are required to mediate Dorsal Organ Cool Cell responses to cooling and are required for cool avoidance behavior.
Title: The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila.
Drosophila IR25a is required for behavioural synchronization to low-amplitude temperature cycles; IR25a is required for temperature-synchronized clock protein oscillations in subsets of central clock neurons
Title: Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature.
IR8a and IR25a are essential for odor-evoked electrophysiological responses in multiple distinct neuron classes.
Title: Functional architecture of olfactory ionotropic glutamate receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables coreceptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	ISM Inferred from Sequence Model more info	PubMed
contributes_to olfactory receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in temperature compensation of the circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with sensory dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in sensory dendrite	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ionotropic receptor 25a

Names: CG15627-PB; CG15627-PC; CG15627-PD; CG15627-PE; Ir25a-PB; Ir25a-PC; Ir25a-PD; Ir25a-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

4830846..4835300 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135019.2 → NP_608863.2 ionotropic receptor 25a, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608863.2

Status: REVIEWED

UniProtKB/TrEMBL

C6TPA2, Q9VR32

Conserved Domains (3) summary

cd06383
Location:26 → 413

PBP1_iGluR_AMPA_Like; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of uncharacterized AMPA-like receptors

cd13717
Location:425 → 823

PBP2_iGluR_putative; The ligand-binding domain of putative ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:552 → 857

Lig_chan; Ligand-gated ion channel
NM_001273122.1 → NP_001260051.1 ionotropic receptor 25a, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260051.1

Status: REVIEWED

UniProtKB/TrEMBL

C6TPA2, Q9VR32

Conserved Domains (3) summary

cd06383
Location:26 → 413

PBP1_iGluR_AMPA_Like; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of uncharacterized AMPA-like receptors

cd13717
Location:425 → 823

PBP2_iGluR_putative; The ligand-binding domain of putative ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:552 → 857

Lig_chan; Ligand-gated ion channel
NM_001273120.1 → NP_001260049.1 ionotropic receptor 25a, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260049.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E9NA96

UniProtKB/TrEMBL

C6TPA2

Conserved Domains (3) summary

cd06383
Location:40 → 426

PBP1_iGluR_AMPA_Like; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of uncharacterized AMPA-like receptors

cd13717
Location:438 → 836

PBP2_iGluR_putative; The ligand-binding domain of putative ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:565 → 870

Lig_chan; Ligand-gated ion channel
NM_001273121.1 → NP_001260050.1 ionotropic receptor 25a, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260050.1

Status: REVIEWED

UniProtKB/TrEMBL

C6TPA2, M9PC56

Conserved Domains (3) summary

cd06383
Location:19 → 408

PBP1_iGluR_AMPA_Like; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of uncharacterized AMPA-like receptors

cd13717
Location:420 → 818

PBP2_iGluR_putative; The ligand-binding domain of putative ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:547 → 852

Lig_chan; Ligand-gated ion channel