U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Srpk79D Serine-arginine protein kinase at 79D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40461, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Srpk79Dprovided by FlyBase
    Official Full Name
    Serine-arginine protein kinase at 79Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025702
    Locus tag
    Dmel_CG11489
    See related
    AllianceGenome:FB:FBgn0025702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atc; BEST:CK01209; CG11489; CG9085; CK01209; Dmel\CG11489; SRPK; SRPK1; srpk79d; srpk79D; SRPK79D
    Summary
    Enables protein kinase activity. Involved in several processes, including cytoskeletal matrix organization at active zone; defense response to bacterium; and presynaptic active zone organization. Located in axon terminus and presynaptic active zone. Is expressed in adult head; larval central nervous system; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Srpk79D in Genome Data Viewer
    Location:
    79D4-79D4; 3-47 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22273985..22284335)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22267085..22277435)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Dead-box-1 Neighboring gene uncharacterized protein Neighboring gene Cysteine string protein Neighboring gene stable intronic sequence RNA 3 Neighboring gene antisense RNA:CR45960 Neighboring gene HEM-protein Neighboring gene Isoleucyl-tRNA synthetase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The role of SR protein kinases in regulating lipid storage in the Drosophila fat body. Mercier J, et al. Biochem Biophys Res Commun, 2023 Mar 15. PMID 36738578
    2. Neuronal LRP4 directs the development, maturation and cytoskeletal organization of Drosophila peripheral synapses. DePew AT, et al. Development, 2024 Jun 1. PMID 38738619, Free PMC Article
    3. Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila. Nieratschker V, et al. PLoS Genet, 2009 Oct. PMID 19851455, Free PMC Article
    4. Presynaptic LRP4 promotes synapse number and function of excitatory CNS neurons. Mosca TJ, et al. Elife, 2017 Jun 13. PMID 28606304, Free PMC Article
    5. Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks. Driller JH, et al. J Cell Sci, 2019 Mar 18. PMID 30745339

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of SR protein kinases in regulating lipid storage in the Drosophila fat body.
      Title: The role of SR protein kinases in regulating lipid storage in the Drosophila fat body.
    2. Mutation of the Srpk79D gene causes conspicuous accumulations of BRP in larval and adult nerves.
      Title: Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila.
    3. SRPK79D is a novel T-bar-associated protein kinase that represses T-bar assembly in peripheral axons, and that SRPK79D-dependent repression must be relieved to facilitate site-specific AZ assembly.
      Title: Negative regulation of active zone assembly by a newly identified SR protein kinase.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeletal matrix organization at active zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic active zone organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Serine-arginine protein kinase at 79D
    Names
    CG11489-PB
    CG11489-PE
    CG11489-PF
    CG11489-PH
    CG11489-PI
    CG11489-PJ
    CG11489-PK
    CG11489-PL
    CG11489-PM
    CG11489-PN
    CG11489-PO
    Srpk79D-PB
    Srpk79D-PE
    Srpk79D-PF
    Srpk79D-PH
    Srpk79D-PI
    Srpk79D-PJ
    Srpk79D-PK
    Srpk79D-PL
    Srpk79D-PM
    Srpk79D-PN
    Srpk79D-PO
    air traffic controller
    serine-arginine (SR) protein kinase at location 79D
    serine-arginine protein kinase at 79D
    NP_001097660.2
    NP_001189160.1
    NP_001189161.1
    NP_001246879.1
    NP_001246880.1
    NP_001246881.1
    NP_001246882.1
    NP_001262208.1
    NP_001262209.1
    NP_001262210.1
    NP_649387.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22273985..22284335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202232.3 → NP_001189161.1  Serine-arginine protein kinase at 79D, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS50
      Conserved Domains (2) summary
      smart00220
      Location:347 → 492
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:336 → 863
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    2. NM_001259951.2 → NP_001246880.1  Serine-arginine protein kinase at 79D, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEI4
      Conserved Domains (2) summary
      smart00220
      Location:347 → 492
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:791 → 959
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    3. NM_001104190.4 → NP_001097660.2  Serine-arginine protein kinase at 79D, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097660.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNV0
      Conserved Domains (3) summary
      smart00220
      Location:347 → 810
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:336 → 810
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
      cl21453
      Location:457 → 534
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001259952.2 → NP_001246881.1  Serine-arginine protein kinase at 79D, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NGC6
      Conserved Domains (2) summary
      smart00220
      Location:347 → 492
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:844 → 1012
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    5. NM_001202231.2 → NP_001189160.1  Serine-arginine protein kinase at 79D, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDA8
      Conserved Domains (2) summary
      smart00220
      Location:280 → 425
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:269 → 796
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    6. NM_141130.4 → NP_649387.2  Serine-arginine protein kinase at 79D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649387.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3S1, Q9VNU9
      Related
      FBpp0078148
      Conserved Domains (3) summary
      smart00220
      Location:280 → 743
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:269 → 743
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
      cl21453
      Location:390 → 467
      PKc_like; Protein Kinases, catalytic domain

    7. NM_001275279.1 → NP_001262208.1  Serine-arginine protein kinase at 79D, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIK8
      Conserved Domains (3) summary
      smart00220
      Location:280 → 425
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:776 → 944
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
      pfam09007
      Location:605 → 680
      EBP50_C; EBP50, C-terminal

    8. NM_001275280.1 → NP_001262209.1  Serine-arginine protein kinase at 79D, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDA8
      Conserved Domains (2) summary
      smart00220
      Location:280 → 425
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:269 → 796
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    9. NM_001275281.1 → NP_001262210.1  Serine-arginine protein kinase at 79D, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3S1, Q9VNU9
      Conserved Domains (3) summary
      smart00220
      Location:280 → 743
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:269 → 743
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
      cl21453
      Location:390 → 467
      PKc_like; Protein Kinases, catalytic domain

    10. NM_001259953.2 → NP_001246882.1  Serine-arginine protein kinase at 79D, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246882.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDF9
      Conserved Domains (2) summary
      smart00220
      Location:280 → 425
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:777 → 945
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase

    11. NM_001259950.2 → NP_001246879.1  Serine-arginine protein kinase at 79D, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDZ1
      Conserved Domains (2) summary
      smart00220
      Location:280 → 425
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14136
      Location:724 → 892
      STKc_SRPK; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MS50 M9MS50
    M9NDF9 M9NDF9
    M9NDZ1 M9NDZ1
    M9NEI4 M9NEI4
    M9NGC6 M9NGC6
    M9PDA8 M9PDA8
    M9PIK8 M9PIK8
    Q8SWX7 Q8SWX7
    Q8T3S1 Q8T3S1
    Q9VNV0 Q9VNV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools