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    ciaR two-component system response regulator CiaR [ Streptococcus pseudopneumoniae IS7493 ]

    Gene ID: 45218124, updated on 3-Dec-2024

    Summary

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    Gene symbol
    ciaR
    Gene description
    two-component system response regulator CiaR
    Locus tag
    SPPN_RS04030
    Gene type
    protein coding
    Organism
    Streptococcus pseudopneumoniae IS7493 (strain: IS7493)
    Lineage
    Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
    Old locus tag
    SPPN_04090
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    Genomic context

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    Sequence:
    NC_015875.1 (775419..776093)

    NC_015875.1Genomic Context describing neighboring genes Neighboring gene putative PEP-binding protein Neighboring gene ASCH domain-containing protein Neighboring gene M1 family metallopeptidase Neighboring gene two-component system sensor histidine kinase CiaH Neighboring gene DUF3270 domain-containing protein Neighboring gene peptidase U32 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015875.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of CiaR Regulated Genes That Promote Group B Streptococcal Virulence and Interaction with Brain Endothelial Cells. Mu R, et al. PLoS One, 2016. PMID 27100296, Free PMC Article
    2. Identification of the genes directly controlled by the response regulator CiaR in Streptococcus pneumoniae: five out of 15 promoters drive expression of small non-coding RNAs. Halfmann A, et al. Mol Microbiol, 2007 Oct. PMID 17725562
    3. The CiaRH system of Streptococcus pneumoniae prevents lysis during stress induced by treatment with cell wall inhibitors and by mutations in pbp2x involved in beta-lactam resistance. Mascher T, et al. J Bacteriol, 2006 Mar. PMID 16484208, Free PMC Article
    4. Target evaluation of the non-coding csRNAs reveals a link of the two-component regulatory system CiaRH to competence control in Streptococcus pneumoniae R6. Schnorpfeil A, et al. Mol Microbiol, 2013 Jul. PMID 23710838
    5. Effect of new alleles of the histidine kinase gene ciaH on the activity of the response regulator CiaR in Streptococcus pneumoniae R6. Müller M, et al. Microbiology (Reading), 2011 Nov. PMID 21903754

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    two-component system response regulator CiaR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015875.1 Reference assembly

      Range
      775419..776093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_000590626.1 MULTISPECIES: two-component system response regulator CiaR [Streptococcus]

      UniProtKB/TrEMBL
      A0A0T8TLG1, A0A1S9Z7X1
      Conserved Domains (1) summary
      COG0745
      Location:3 → 222
      OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    Nucleotide Protein
    Heading Accession and Version

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