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    hipA type II toxin-antitoxin system serine/threonine protein kinase toxin HipA [ Shigella boydii ]

    Gene ID: 75202245, updated on 3-Dec-2024

    Summary

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    Gene symbol
    hipA
    Gene description
    type II toxin-antitoxin system serine/threonine protein kinase toxin HipA
    Locus tag
    CEH00_RS01550
    Gene type
    protein coding
    Organism
    Shigella boydii (strain: ESBL-W3-2, nat-host: Homo sapiens)
    Lineage
    Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella
    Old locus tag
    CEH00_01550
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    Genomic context

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    NZ_NIYS01000012.1Genomic Context describing neighboring genes Neighboring gene type 1 fimbrial major subunit FimA Neighboring gene pseudo Neighboring gene pseudo Neighboring gene type II toxin-antitoxin system antitoxin HipB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NZ_NIYS01000012.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ectopic overexpression of wild-type and mutant hipA genes in Escherichia coli: effects on macromolecular synthesis and persister formation. Korch SB, et al. J Bacteriol, 2006 Jun. PMID 16707675, Free PMC Article
    2. HipBA-promoter structures reveal the basis of heritable multidrug tolerance. Schumacher MA, et al. Nature, 2015 Aug 6. PMID 26222023, Free PMC Article
    3. hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis. Moyed HS, et al. J Bacteriol, 1983 Aug. PMID 6348026, Free PMC Article
    4. Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Schumacher MA, et al. Science, 2009 Jan 16. PMID 19150849, Free PMC Article
    5. Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis. Black DS, et al. J Bacteriol, 1994 Jul. PMID 8021189, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    type II toxin-antitoxin system serine/threonine protein kinase toxin HipA
    WP_001125463.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NZ_NIYS01000012.1 Reference assembly

      Range
      10041..11363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_001125463.1 MULTISPECIES: type II toxin-antitoxin system serine/threonine protein kinase toxin HipA [Enterobacteriaceae]

      See identical proteins and their annotated locations for WP_001125463.1

      UniProtKB/TrEMBL
      A0A2A2XPR2, A0A6H2GQI4, A0A7U9IYX0, A0A9Q5XZW3, A0AAD2YWI0, A0AAN3M7A3, A0AAN3SNA2, A0AAN3V0L0, B7L7K8, J7Q7H5
      Conserved Domains (1) summary
      cd17808
      Location:20 → 435
      HipA_Ec_like; type II toxin-antitoxin sytem toxin HipA from Escherichia coli and similar proteins
    Nucleotide Protein
    Heading Accession and Version