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    T19B10.5 PDZ domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179553, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T19B10.5
    Official Full Name
    PDZ domain-containing protein
    Primary source
    WormBase:WBGene00011833
    Locus tag
    CELE_T19B10.5
    See related
    AllianceGenome:WB:WBGene00011833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane and nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 3 and Charcot-Marie-Tooth disease type 4F. Orthologous to human AHNAK2 (AHNAK nucleoprotein 2) and PRX (periaxin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T19B10.5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (11234650..11237427)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-dependent metalloprotease dvc-1 Neighboring gene ncRNA Neighboring gene Importin subunit alpha-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PDZ domain-containing protein
    NP_505852.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11234650..11237427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073451.8 → NP_505852.3  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505852.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22559
      Conserved Domains (2) summary
      PTZ00449
      Location:340 → 483
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00228
      Location:137 → 208
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    Nucleotide Protein
    Heading Accession and Version

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