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    MFSD13A major facilitator superfamily domain containing 13A [ Homo sapiens (human) ]

    Gene ID: 79847, updated on 10-Dec-2024

    Summary

    Official Symbol
    MFSD13Aprovided by HGNC
    Official Full Name
    major facilitator superfamily domain containing 13Aprovided by HGNC
    Primary source
    HGNC:HGNC:26196
    See related
    Ensembl:ENSG00000138111 MIM:620255; AllianceGenome:HGNC:26196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM180; C10orf77; bA18I14.8
    Summary
    Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 9.0), lung (RPKM 6.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MFSD13A in Genome Data Viewer
    Location:
    10q24.32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102461395..102477045)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103346383..103362022)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104221152..104236802)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene C10orf95 antisense RNA 1 Neighboring gene microRNA 146b Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104211267-104211949 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:104214138-104214726 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:104214727-104215314 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:104215315-104215904 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:104215905-104216492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104216493-104217081 Neighboring gene uncharacterized LOC124902493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3937 Neighboring gene chromosome 10 open reading frame 95 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104220868-104221551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104221552-104222234 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:104233222-104233665 Neighboring gene actin related protein 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104260453-104260953 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2764 Neighboring gene Sharpr-MPRA regulatory region 236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104264916-104265416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3939 Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3940 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:104325435-104326134 Neighboring gene ribosomal protein L23a pseudogene 58

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22529

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024789.4NP_079065.2  transmembrane protein 180

      See identical proteins and their annotated locations for NP_079065.2

      Status: VALIDATED

      Source sequence(s)
      AL121928, BC057787, BG830198
      Consensus CDS
      CCDS7535.1
      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
      Related
      ENSP00000238936.3, ENST00000238936.8
      Conserved Domains (1) summary
      cl26210
      Location:23426
      MFS_2; MFS/sugar transport protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      102461395..102477045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540160.3XP_011538462.1  transmembrane protein 180 isoform X1

      See identical proteins and their annotated locations for XP_011538462.1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
      Conserved Domains (1) summary
      cl26210
      Location:23426
      MFS_2; MFS/sugar transport protein
    2. XM_006717973.4XP_006718036.1  transmembrane protein 180 isoform X1

      See identical proteins and their annotated locations for XP_006718036.1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
      Conserved Domains (1) summary
      cl26210
      Location:23426
      MFS_2; MFS/sugar transport protein
    3. XM_024448171.2XP_024303939.1  transmembrane protein 180 isoform X2

    4. XM_011540163.3XP_011538465.1  transmembrane protein 180 isoform X1

      See identical proteins and their annotated locations for XP_011538465.1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
      Conserved Domains (1) summary
      cl26210
      Location:23426
      MFS_2; MFS/sugar transport protein
    5. XM_047425757.1XP_047281713.1  transmembrane protein 180 isoform X2

    6. XM_017016654.2XP_016872143.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
      Conserved Domains (1) summary
      cl26210
      Location:23426
      MFS_2; MFS/sugar transport protein
    7. XM_047425756.1XP_047281712.1  transmembrane protein 180 isoform X2

    8. XM_047425755.1XP_047281711.1  transmembrane protein 180 isoform X2

    9. XM_006717974.4XP_006718037.1  transmembrane protein 180 isoform X1

      See identical proteins and their annotated locations for XP_006718037.1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
      Conserved Domains (1) summary
      cl26210
      Location:23426
      MFS_2; MFS/sugar transport protein
    10. XM_011540167.3XP_011538469.1  transmembrane protein 180 isoform X2

      See identical proteins and their annotated locations for XP_011538469.1

    11. XM_017016661.2XP_016872150.1  transmembrane protein 180 isoform X3

      Conserved Domains (1) summary
      cl26210
      Location:23276
      MFS_2; MFS/sugar transport protein
    12. XM_017016662.2XP_016872151.1  transmembrane protein 180 isoform X3

      Conserved Domains (1) summary
      cl26210
      Location:23276
      MFS_2; MFS/sugar transport protein
    13. XM_047425759.1XP_047281715.1  transmembrane protein 180 isoform X3

    14. XM_024448172.2XP_024303940.1  transmembrane protein 180 isoform X3

      Conserved Domains (1) summary
      cl26210
      Location:23276
      MFS_2; MFS/sugar transport protein
    15. XM_047425751.1XP_047281707.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    16. XM_047425753.1XP_047281709.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    17. XM_017016655.1XP_016872144.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
      Conserved Domains (1) summary
      cl26210
      Location:23426
      MFS_2; MFS/sugar transport protein
    18. XM_047425752.1XP_047281708.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    19. XM_047425758.1XP_047281714.1  transmembrane protein 180 isoform X2

    20. XM_047425754.1XP_047281710.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    21. XM_047425760.1XP_047281716.1  transmembrane protein 180 isoform X4

      UniProtKB/TrEMBL
      B4DKJ1
    22. XM_047425761.1XP_047281717.1  transmembrane protein 180 isoform X4

      UniProtKB/TrEMBL
      B4DKJ1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      103346383..103362022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366742.1XP_054222717.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    2. XM_054366738.1XP_054222713.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    3. XM_054366748.1XP_054222723.1  transmembrane protein 180 isoform X2

    4. XM_054366739.1XP_054222714.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    5. XM_054366749.1XP_054222724.1  transmembrane protein 180 isoform X2

    6. XM_054366736.1XP_054222711.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    7. XM_054366747.1XP_054222722.1  transmembrane protein 180 isoform X2

    8. XM_054366746.1XP_054222721.1  transmembrane protein 180 isoform X2

    9. XM_054366737.1XP_054222712.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    10. XM_054366750.1XP_054222725.1  transmembrane protein 180 isoform X2

    11. XM_054366752.1XP_054222727.1  transmembrane protein 180 isoform X3

    12. XM_054366753.1XP_054222728.1  transmembrane protein 180 isoform X3

    13. XM_054366754.1XP_054222729.1  transmembrane protein 180 isoform X3

    14. XM_054366755.1XP_054222730.1  transmembrane protein 180 isoform X3

    15. XM_054366740.1XP_054222715.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    16. XM_054366743.1XP_054222718.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    17. XM_054366744.1XP_054222719.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    18. XM_054366741.1XP_054222716.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    19. XM_054366751.1XP_054222726.1  transmembrane protein 180 isoform X2

    20. XM_054366745.1XP_054222720.1  transmembrane protein 180 isoform X1

      UniProtKB/Swiss-Prot
      Q14CX5, Q6NWM8, Q6NWM9, Q6PEZ7, Q9H679
    21. XM_054366756.1XP_054222731.1  transmembrane protein 180 isoform X4

      UniProtKB/TrEMBL
      B4DKJ1
    22. XM_054366757.1XP_054222732.1  transmembrane protein 180 isoform X4

      UniProtKB/TrEMBL
      B4DKJ1