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    Lst Limostatin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lstprovided by FlyBase
    Official Full Name
    Limostatinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034140
    Locus tag
    Dmel_CG8317
    See related
    AllianceGenome:FB:FBgn0034140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8317; Dmel\CG8317; lst
    Summary
    Involved in several processes, including glucose homeostasis; negative regulation of peptide hormone secretion; and triglyceride homeostasis. Is expressed in corpus cardiacum. Used to study obesity. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lst in Genome Data Viewer
    Location:
    53C8-53C8; 2-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16574579..16576586, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12462084..12464091, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S15 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44375 Neighboring gene Cyclin-dependent kinase 4 Neighboring gene Ribosomal protein LP2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster Limostatin and Its Human Ortholog Promote West Nile Virus Infection. Mead EB, et al. Insects, 2024 Jun 12. PMID 38921161, Free PMC Article
    2. Suppression of insulin production and secretion by a decretin hormone. Alfa RW, et al. Cell Metab, 2015 Feb 3. PMID 25651184, Free PMC Article
    3. Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila. Meschi E, et al. Neuron, 2024 Jul 17. PMID 38795709
    4. Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster. Chng WA, et al. Trends Endocrinol Metab, 2017 Feb. PMID 27923532
    5. Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila. Kim SK, et al. Cell Metab, 2021 Jul 6. PMID 34139200, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cellular response to carbohydrate stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptide hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    limostatin
    Names
    CG8317-PA
    CG8317-PB
    CG8317-PC
    Lst-PA
    Lst-PB
    Lst-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16574579..16576586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137294.3 → NP_611138.2  limostatin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611138.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NPB2
      Related
      FBpp0086268

    2. NM_001259439.2 → NP_001246368.1  limostatin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246368.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K762

    3. NM_001259440.2 → NP_001246369.1  limostatin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7D0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K762 A0A0B4K762
    A0A0B4K7D0 A0A0B4K7D0
    Q6NPB2 Q6NPB2

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